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Bhoomika Sherkhane
Publications - 11
Citations - 158
Bhoomika Sherkhane is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 6 publications receiving 58 citations.
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Journal ArticleDOI
Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy.
TL;DR: Results from this study signify the importance of mitoprotection conferred by BRB in DN and can be used as a preliminary basis for further molecular exploration.
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SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy
TL;DR: Study results inferred that decline in mitochondrial biogenesis and oxidative function in diabetic rats and high-glucose-exposed Neuro2a cells, could be counteracted by polydatin administration, postulated via enhancing SIRT1 and Nrf2 axis.
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Bardoxolone Methyl Ameliorates Hyperglycemia Induced Mitochondrial Dysfunction by Activating the keap1-Nrf2-ARE Pathway in Experimental Diabetic Neuropathy
Anil Kumar Kalvala,Rajesh Kumar,Bhoomika Sherkhane,Chayanika Gundu,Vijay Kumar Arruri,Ashutosh Kumar +5 more
TL;DR: The data suggests that Bard treatment to STZ induced diabetic rats robustly reduces DN which may be due to its effect on Keap1-Nrf2-ARE pathway and have contributed to improvement in mitochondrial function.
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Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation
Anil Kumar Kalvala,Veera Ganesh Yerra,Bhoomika Sherkhane,Chayanika Gundu,Vijay Kumar Arruri,Rajesh Kumar,Ashutosh Kumar +6 more
TL;DR: The results would signify the importance of modulating mitochondrial proteases for the therapeutic management of DN and suggest that siRNA directed against Lonp1 has impaired the activity of Resveratrol in attenuating the HG induced mitochondrial dysfunction.
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Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1/Nrf-2/p62 directed autophagy and mitochondrial quality control in neuropathic pain.
Vijay Kumar Arruri,Chayanika Gundu,Anil Kumar Kalvala,Bhoomika Sherkhane,Dharmendra Kumar Khatri,Shashi Bala Singh +5 more
TL;DR: In this article, the effect of carvacrol (CRC), a phenolic monoterpene with high nutritional value on NLRP3 activation against chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain (NP) in rats and in lipopolysacharide (LPS) induced neuroinflammation in neuro2a (N2A) cells.