B
Billy R. Martin
Researcher at Virginia Commonwealth University
Publications - 391
Citations - 28760
Billy R. Martin is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Cannabinoid & Cannabinoid receptor. The author has an hindex of 87, co-authored 391 publications receiving 27667 citations. Previous affiliations of Billy R. Martin include Clemson University & VCU Medical Center.
Papers
More filters
Journal ArticleDOI
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
Raphael Mechoulam,Shimon Ben-Shabat,Lumir Hanus,Moshe Ligumsky,Norbert E. Kaminski,Anthony R. Schatz,Asher Gopher,Shlomo Almog,Billy R. Martin,David R. Compton,Roger G. Pertwee,Graeme Griffin,Michael Bayewitch,Jacob Barg,Zvi Vogel +14 more
TL;DR: Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature.
Journal ArticleDOI
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
Benjamin F. Cravatt,Kristin Demarest,Matthew P. Patricelli,Michael H. Bracey,Dan K. Giang,Billy R. Martin,Aron H. Lichtman +6 more
TL;DR: Results indicate that FAAH is a key regulator of anandamide signaling in vivo, setting an endogenous cannabinoid tone that modulates pain perception, and may represent an attractive pharmaceutical target for the treatment of pain and neuropsychiatric disorders.
Journal ArticleDOI
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
Zoltán Járai,Jens A. Wagner,Jens A. Wagner,Károly Varga,Kristy D. Lake,D R Compton,Billy R. Martin,Anne M. Zimmer,Tom I. Bonner,Nancy E. Buckley,Eva Mezey,Raj K. Razdan,Andreas Zimmer,George Kunos +13 more
TL;DR: It is suggested that Abn-cbd and cannabidiol are a selective agonist and antagonist, respectively, of an as-yet-unidentified endothelial receptor for anandamide, activation of which elicits NO-independent mesenteric vasodilation, possibly by means of the release of an endothelium-derived hyperpolarizing factor (EDHF).
Journal ArticleDOI
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
TL;DR: Assays of different central nervous system (CNS) regions demonstrated significant activity of cannabinoids in CB(1)(-/-) membranes from brain stem, cortex, hippocampus, diencephalon, midbrain, and spinal cord, but not basal ganglia or cerebellum.
Journal ArticleDOI
Cannabis: pharmacology and toxicology in animals and humans.
Irma B. Adams,Billy R. Martin +1 more
TL;DR: The advent of highly potent analogs and a specific antagonist may make possible the development of compounds that lack undesirable side effects, thus limiting therapeutic usefulness of cannabinoid-derived drugs on the market today.