Z
Zvi Vogel
Researcher at Weizmann Institute of Science
Publications - 127
Citations - 10819
Zvi Vogel is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Receptor & Cannabinoid receptor. The author has an hindex of 46, co-authored 126 publications receiving 10368 citations. Previous affiliations of Zvi Vogel include Israel Institute for Biological Research & Wolfson Medical Center.
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Journal ArticleDOI
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
Raphael Mechoulam,Shimon Ben-Shabat,Lumir Hanus,Moshe Ligumsky,Norbert E. Kaminski,Anthony R. Schatz,Asher Gopher,Shlomo Almog,Billy R. Martin,David R. Compton,Roger G. Pertwee,Graeme Griffin,Michael Bayewitch,Jacob Barg,Zvi Vogel +14 more
TL;DR: Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature.
Journal ArticleDOI
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
Lumir Hanus,Saleh Abu-Lafi,Ester Fride,Aviva Breuer,Zvi Vogel,Deborah E. Shalev,Irina Kustanovich,Raphael Mechoulam +7 more
TL;DR: Two types of endogenous cannabinoid-receptor agonists have been identified thus far and an example of a third, ether-type endocannabinoid, 2-arachidonyl glyceryl ether (noladin ether), isolated from porcine brain is reported.
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An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.
Shimon Ben-Shabat,Ester Fride,Tzviel Sheskin,Tsippy Tamiri,Man Hee Rhee,Zvi Vogel,Tiziana Bisogno,Luciano De Petrocellis,Vincenzo Di Marzo,Raphael Mechoulam +9 more
TL;DR: The data indicate that the biological activity of 2-Ara-Gl can be increased by related, endogenous 2-acyl-glycerols, which alone show no significant activity in any of the tests employed, suggesting that this effect ('entourage effect') may represent a novel route for molecular regulation of endogenous cannabinoid activity.
Journal ArticleDOI
Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors
R. Maggio,Zvi Vogel,Jürgen Wess +2 more
TL;DR: In this paper, the C-terminal receptor portions (containing transmembrane domains VI and VII) were exchanged between the alpha 2C-adrenergic and the m3 muscarinic receptor.
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Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase.
TL;DR: Data indicate that anandamide is an endogenous agonist that may serve as a genuine neurotransmitter for the cannabinoid receptor and was blocked by treatment with pertussis toxin.