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Bin Lan
Publications - 10
Citations - 337
Bin Lan is an academic researcher. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 2, co-authored 2 publications receiving 137 citations.
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Journal ArticleDOI
Chemoresistance in Pancreatic Cancer.
TL;DR: New perspectives for enhancing the efficacy of gemcitabine are outlined after reviewing the related factors of gem citabine metabolism, mechanism of action, and chemoresistance.
Journal ArticleDOI
The Role of Exosomes in Pancreatic Cancer.
TL;DR: The role of exosomes in the proliferation, metastasis and chemoresistance, as well as their potential applications for pancreatic cancer are focused on.
Journal ArticleDOI
CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
Bin Lan,Siyuan Zeng,Shuman Zhang,Xiaofan Ren,Yuming Xing,Isabella Kutschick,Susanne Petra Pfeffer,Benjamin Frey,Nathalie Britzen-Laurent,Robert Grützmann,Nils Cordes,Christian Pilarsky +11 more
TL;DR: It is demonstrated that the harmine-targeted suppression of DYRK1A used in conjunction with radiotherapy increases DNA double-strand breaks and impairs homologous repair (HR), resulting in more cancer cell death, and the use of CRISPR-Cas9 screening to identify new therapeutic targets, develop radiosensitizers, and provide novel strategies for overcoming the tolerance of pancreatic cancer to radiotherapy.
Journal ArticleDOI
An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy
Jingmin Lin,Jun Liu,Shiguang Hao,Bin Lan,Xiao Zheng,Jiani Xiong,Yingqi Zhang,Xuan Gao,Chuanben Chen,Ling-xiao Chen,Yu-Fang Huang,Hong Luo,Yuting Yi,Xin Yi,Jianping Lu,Xiongwei Zheng,Gang Chen,Xuefeng Wang,Yu Chen +18 more
TL;DR: In this paper , a vaccine that targets mutation-derived neoantigen in Chinese non-small-cell lung cancer (NSCLC) patients was developed to develop a vaccine.
Journal ArticleDOI
Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells
Xuefeng Wang,Yu Chen,Bin Lan,Yu Wang,Wan-Song Lin,Xuehua Jiang,Jiayin Ye,Bingxue Shang,Chao Feng,Jun Liu,Jingjie Zhai,Qing Li,Liangyu Lin,Ming Hu,Fanjun Zheng,Ling-xiao Chen,Changshun Shao,Ying Wang,Yufang Shi +18 more
TL;DR: The heterogeneity of melanoma cells in utilization of tyrosine is associated with organotropic colonization, providing the basis for developing new strategies to combat melanoma.