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Bindu D. Paul
Researcher at Johns Hopkins University School of Medicine
Publications - 73
Citations - 5810
Bindu D. Paul is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurodegeneration & Thyroid hormone receptor. The author has an hindex of 31, co-authored 61 publications receiving 4294 citations. Previous affiliations of Bindu D. Paul include Johns Hopkins University & National Institutes of Health.
Papers
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Journal ArticleDOI
H2S signalling through protein sulfhydration and beyond
Bindu D. Paul,Solomon H. Snyder +1 more
TL;DR: Physiological actions of sulfhydration include the regulation of inflammation and endoplasmic reticulum stress signalling as well as of vascular tension.
Journal ArticleDOI
Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions.
Nilkantha Sen,Bindu D. Paul,Moataz M. Gadalla,Asif K. Mustafa,Tanusree Sen,Risheng Xu,Seyun Kim,Solomon H. Snyder +7 more
TL;DR: Sulfhydration of NF-κB appears to be a physiologic determinant of its antiapoptotic transcriptional activity and may contribute to alterations in CSE mutant mice.
Journal ArticleDOI
Bilirubin and glutathione have complementary antioxidant and cytoprotective roles
Thomas W. Sedlak,Masoumeh Saleh,Daniel S. Higginson,Bindu D. Paul,Krishna R. Juluri,Solomon H. Snyder +5 more
TL;DR: It is shown that the water-soluble GSH primarily protects water soluble proteins, whereas the lipophilic bilirubin protects lipids from oxidation, and that RNA interference depletion of BVR increases oxidation of lipids more than protein.
Journal ArticleDOI
Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease
Bindu D. Paul,Juan I. Sbodio,Risheng Xu,M. Scott Vandiver,Jiyoung Y. Cha,Adele M. Snowman,Solomon H. Snyder +6 more
TL;DR: A major depletion of cystathionine γ-lyase (CSE), the biosynthetic enzyme for cysteine, is shown in Huntington's disease tissues, which may mediate Huntington’s disease pathophysiology.
Journal ArticleDOI
H2S: A Novel Gasotransmitter that Signals by Sulfhydration.
Bindu D. Paul,Solomon H. Snyder +1 more
TL;DR: This review focuses on sulfhydration (or persulfidation), which appears to be the principal post-translational modification elicited by H2S.