J
Jiyoung Y. Cha
Researcher at Johns Hopkins University School of Medicine
Publications - 13
Citations - 834
Jiyoung Y. Cha is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Signal transduction & Inositol. The author has an hindex of 11, co-authored 13 publications receiving 700 citations. Previous affiliations of Jiyoung Y. Cha include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease
Bindu D. Paul,Juan I. Sbodio,Risheng Xu,M. Scott Vandiver,Jiyoung Y. Cha,Adele M. Snowman,Solomon H. Snyder +6 more
TL;DR: A major depletion of cystathionine γ-lyase (CSE), the biosynthetic enzyme for cysteine, is shown in Huntington's disease tissues, which may mediate Huntington’s disease pathophysiology.
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Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2
Feng Rao,Jiyoung Y. Cha,Jing Xu,Risheng Xu,M. Scott Vandiver,Richa Tyagi,Robert Tokhunts,Michael A. Koldobskiy,Chenglai Fu,Roxanne K. Barrow,Mingxuan Wu,Dorothea Fiedler,James C. Barrow,Solomon H. Snyder +13 more
TL;DR: It is demonstrated that IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the TTT complex, thereby stabilizing DNA-PKcs and ATM and stimulating p53 phosphorylated at serine 15 to activate the cell death program in human cancer cells and in murine B cells.
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Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform
TL;DR: The data support a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling.
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Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
Scott A. Chasse,Paul L. Flanary,Stephen C. Parnell,Nan Hao,Jiyoung Y. Cha,David P. Siderovski,Henrik G. Dohlman +6 more
TL;DR: It is suggested that Sst2 is the principal regulator of Gpa1-mediated signaling in vivo but that other proteins also contribute in distinct ways to pathway regulation.
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Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1
Feng Rao,Jing Xu,Chenglai Fu,Jiyoung Y. Cha,Moataz M. Gadalla,Risheng Xu,James C. Barrow,Solomon H. Snyder +7 more
TL;DR: The catalytic activity of inositol hexakisphosphate kinase 2 (IP6K2), one of the principal enzymes generating the inositl pyrophosphate IP7, mediates cancer cell migration and tumor metastasis both in cell culture and intact mice.