Bing Fang

TL;DR: The results are the first to elucidate the specific effect of each ion from bioceramics on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration, paving the way for the design of functional biomaterials with complex compositions for tissue engineering and regenerative medicine.

TL;DR: The results suggest that HAp bioceramic scaffolds with micro-nano-hybrid surface can act as cell carrier for ASCs, and consequently combine with ASCs to construct vascularized tissue-engineered bone.

TL;DR: β-TCP-GRA scaffolds led to an increased rate of in vivo new bone formation compared to β- TCP controls, indicative of the stimulatory effect of GO on in vivo osteogenesis, making GO modification of β-TCp a very promising method for applications in bone tissue engineering, in particular for the regeneration of large bone defects.

TL;DR: The results suggest that application of the MBG nanolayer to modify 3D-printed bioceramic scaffolds offers a new strategy to construct hierarchically porous scaffolds with significantly improved physicochemical and biological properties, such as mechanical properties, osteogenesis, angiogenesis and protein expression.

TL;DR: Results suggest that akermanite bioceramics with the effects of Mg and Si ions on osteogenesis, angiogenesis and osteoclastogenesis are promising biomaterials for osteoporotic bone regeneration.