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Bingchen Han
Researcher at Cedars-Sinai Medical Center
Publications - 32
Citations - 1099
Bingchen Han is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Breast cancer & Uterus. The author has an hindex of 15, co-authored 31 publications receiving 790 citations. Previous affiliations of Bingchen Han include Xiamen University & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Evaluation of MCF10A as a Reliable Model for Normal Human Mammary Epithelial Cells
Ying Qu,Bingchen Han,Yi Yu,Weiwu Yao,Shikha Bose,Beth Y. Karlan,Armando E. Giuliano,Xiaojiang Cui +7 more
TL;DR: In this paper, the MCF10A cells were grown in monolayer, suspension (mammosphere culture), three-dimensional (3D) “on-top” Matrigel, 3D “cell-embedded” matrigel or mixed Matrigels/collagen I gel.
Journal ArticleDOI
Breast cancer lung metastasis: Molecular biology and therapeutic implications.
TL;DR: The recent advances regarding the molecular signaling pathways as well as the therapeutic strategies for treating breast cancer lung metastasis are summarized.
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FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
Bingchen Han,Ying Qu,Yanli Jin,Yi Yu,Nan Deng,Kolja Wawrowsky,Xiao Zhang,Na Li,Shikha Bose,Qiang Wang,Sugunadevi Sakkiah,Ravinder Abrol,Tor W. Jensen,Benjamin P. Berman,Hisashi Tanaka,Jeffrey Johnson,Bowen Gao,Jijun Hao,Zhenqiu Liu,Ralph Buttyan,Partha S. Ray,Mien Chie Hung,Mien Chie Hung,Armando E. Giuliano,Xiaojiang Cui +24 more
TL;DR: It is demonstrated that FOXC1 controls cancer stem cell (CSC) properties enriched in BLBC cells via activation of Smoothened (SMO)-independent Hedgehog (Hh) signaling, which is specifically mediated by Gli2.
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FOXC1: an emerging marker and therapeutic target for cancer.
TL;DR: Current knowledge on the function and regulation of FOXC1 in tumor development and progression with a focus on BLBC is summarized, as well as the implications of these new findings in cancer diagnosis and treatment are summarized.
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FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer
Bingchen Han,Bo Zhou,Ying Qu,Bowen Gao,Yali Xu,Stacey Chung,Hisashi Tanaka,Wei Yang,Armando E. Giuliano,Xiaojiang Cui +9 more
TL;DR: A FOXC1-elicited non-canonical WNT5A signaling mechanism comprising NF-κB and MMP7 that is essential for T NBC cell invasiveness is demonstrated, thereby providing implications toward developing an effective therapy for TNBC.