S
Sugunadevi Sakkiah
Researcher at Food and Drug Administration
Publications - 73
Citations - 2068
Sugunadevi Sakkiah is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Pharmacophore & Virtual screening. The author has an hindex of 20, co-authored 70 publications receiving 1580 citations. Previous affiliations of Sugunadevi Sakkiah include Cedars-Sinai Medical Center & Chonnam National University.
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Journal ArticleDOI
Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods
Wenjing Guo,Bohu Pan,Sugunadevi Sakkiah,Gokhan Yavas,Weigong Ge,Wen Zou,Weida Tong,Huixiao Hong +7 more
TL;DR: Potential sources of POP food contamination, analytical approaches to measure POP levels in food and efforts to control food contamination with POPs are described.
Journal ArticleDOI
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
Bingchen Han,Ying Qu,Yanli Jin,Yi Yu,Nan Deng,Kolja Wawrowsky,Xiao Zhang,Na Li,Shikha Bose,Qiang Wang,Sugunadevi Sakkiah,Ravinder Abrol,Tor W. Jensen,Benjamin P. Berman,Hisashi Tanaka,Jeffrey Johnson,Bowen Gao,Jijun Hao,Zhenqiu Liu,Ralph Buttyan,Partha S. Ray,Mien Chie Hung,Mien Chie Hung,Armando E. Giuliano,Xiaojiang Cui +24 more
TL;DR: It is demonstrated that FOXC1 controls cancer stem cell (CSC) properties enriched in BLBC cells via activation of Smoothened (SMO)-independent Hedgehog (Hh) signaling, which is specifically mediated by Gli2.
Journal ArticleDOI
3D QSAR pharmacophore based virtual screening and molecular docking for identification of potential HSP90 inhibitors.
TL;DR: The best five features pharmacophore model, Hypo1, includes two hydrogen bond acceptors, three hydrophobic features, which has the highest correlation coefficient, cost difference, low RMS, and high goodness of fit and enrichment factor.
Journal ArticleDOI
CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity.
Kamel Mansouri,Nicole Kleinstreuer,Ahmed Abdelaziz,Domenico Alberga,Vinicius M. Alves,Vinicius M. Alves,Patrik L. Andersson,Carolina Horta Andrade,Fang Bai,Ilya A. Balabin,Davide Ballabio,Emilio Benfenati,Barun Bhhatarai,Scott Boyer,Jingwen Chen,Viviana Consonni,Sherif Farag,Denis Fourches,Alfonso T. García-Sosa,Paola Gramatica,Francesca Grisoni,Christopher M. Grulke,Huixiao Hong,Dragos Horvath,Xin Hu,Ruili Huang,Nina Jeliazkova,Jiazhong Li,Xuehua Li,Huanxiang Liu,Serena Manganelli,Giuseppe Felice Mangiatordi,Uko Maran,Gilles Marcou,Todd M. Martin,Eugene N. Muratov,Dac-Trung Nguyen,Orazio Nicolotti,Nikolai Georgiev Nikolov,Ulf Norinder,Ester Papa,Michel Petitjean,Geven Piir,Pavel V. Pogodin,Vladimir Poroikov,Xianliang Qiao,Ann M. Richard,Alessandra Roncaglioni,Patricia Ruiz,Chetan Rupakheti,Chetan Rupakheti,Sugunadevi Sakkiah,Alessandro Sangion,Karl-Werner Schramm,Chandrabose Selvaraj,Imran Shah,Sulev Sild,Lixia Sun,Olivier Taboureau,Yun Tang,Igor V. Tetko,Roberto Todeschini,Weida Tong,Daniela Trisciuzzi,Alexander Tropsha,George Van Den Driessche,Alexandre Varnek,Zhongyu Wang,Eva Bay Wedebye,Antony J. Williams,Hongbin Xie,Alexey V. Zakharov,Ziye Zheng,Richard S. Judson +73 more
TL;DR: The Collaborative Modeling Project for Androgen Receptor Activity (CoMPARA) efforts are described, which follows the steps of the Collaborative Estrogen Recept Activity Prediction Project (CERAPP).
Journal ArticleDOI
Homology modeling, molecular dynamics, e-pharmacophore mapping and docking study of Chikungunya virus nsP2 protease
Kh. Dhanachandra Singh,Palani Kirubakaran,Shanthi Nagarajan,Sugunadevi Sakkiah,Karthikeyan Muthusamy,Devadasan Velmurgan,Jeyaraman Jeyakanthan +6 more
TL;DR: A homology model of nsP2 protein based on the crystal structure of the nsP1 protein of Venezuelan equine encephalitis virus is presented, and the pharmacophore features that must be present in an inhibitor of ns P2 protease are proposed.