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Xiaojiang Cui
Researcher at Cedars-Sinai Medical Center
Publications - 99
Citations - 5251
Xiaojiang Cui is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 33, co-authored 91 publications receiving 4422 citations. Previous affiliations of Xiaojiang Cui include Houston Methodist Hospital & Baylor College of Medicine.
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Journal ArticleDOI
Biology of Progesterone Receptor Loss in Breast Cancer and Its Implications for Endocrine Therapy
TL;DR: The biology and etiology of ER-positive/PR-negative breast cancer is discussed, highlighting recent data on molecular cross talk between ER and growth factor signaling pathways and demonstrating how PR might be a useful marker of these activities.
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Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases
Shuying Liu,Makiko Umezu-Goto,Mandi M. Murph,Yiling Lu,Wenbin Liu,Fan Zhang,Shuangxing Yu,L. Clifton Stephens,Xiaojiang Cui,George Murrow,Kevin R. Coombes,William J. Muller,Mien Chie Hung,Charles M. Perou,Adrian V. Lee,Xianjun Fang,Gordon B. Mills +16 more
TL;DR: It is demonstrated that expression of ATX or each edg family LPA receptor in mammary epithelium of transgenic mice is sufficient to induce a high frequency of late-onset, estrogen receptor (ER)-positive, invasive, and metastatic mammary cancer.
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A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Dong-Joo Cheon,Yunguang Tong,Myung-Shin Sim,Judy Dering,Dror Berel,Xiaojiang Cui,Jenny Lester,Jessica A. Beach,Mourad Tighiouart,Ann E. Walts,Beth Y. Karlan,Sandra Orsulic +11 more
TL;DR: Levels of COL11A1, one of the signature genes, continuously increase during ovarian cancer disease progression, with the highest expression in recurrent metastases, and thus may be useful as a therapeutic target.
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Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail
Hyun-Jung Kim,Beate C. Litzenburger,Xiaojiang Cui,David A. Delgado,Brian C. Grabiner,Xin Lin,Michael T. Lewis,Marco M. Gottardis,Tai W. Wong,Ricardo M. Attar,Joan M. Carboni,Adrian V. Lee +11 more
TL;DR: It is found that overexpression of a constitutively activated IGF-IR (CD8-IGF-IR) was sufficient to cause transformation of immortalized human mammary epithelial cells and growth in immunocompromised mice and indicates the hierarchy in the mechanism of IGF-ir-induced EMT.
Journal ArticleDOI
Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer.
Xiaojiang Cui,Ping Zhang,Wanleng Deng,Steffi Oesterreich,Yiling Lu,Gordon B. Mills,Adrian V. Lee +6 more
TL;DR: The results suggest that low PR status may serve as an indicator of activated growth factor signaling in breast tumor cells, and therefore of an aggressive tumor phenotype and resistance against hormonal therapy.