B
Birgit Hollenbach
Researcher at Max Planck Society
Publications - 3
Citations - 1403
Birgit Hollenbach is an academic researcher from Max Planck Society. The author has contributed to research in topics: Protein aggregation & Huntingtin. The author has an hindex of 3, co-authored 3 publications receiving 1364 citations.
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Journal ArticleDOI
Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
Eberhard Scherzinger,Rudi Lurz,Mark Turmaine,Laura Mangiarini,Birgit Hollenbach,Renate Hasenbank,Gillian P. Bates,Stephen W. Davies,Hans Lehrach,Erich E. Wanker +9 more
TL;DR: In this study, it is shown that the proteolytic cleavage of a GST-huntingtin fusion protein leads to the formation of insoluble high molecular weight protein aggregates only when the polyglutamine expansion is in the pathogenic range.
Journal ArticleDOI
Huntingtin aggregation monitored by dynamic light scattering.
Yannis Georgalis,Evgeni B. Starikov,Birgit Hollenbach,Rudi Lurz,Eberhard Scherzinger,Wolfram Saenger,Hans Lehrach,Erich E. Wanker +7 more
TL;DR: An initial stage of fibrillogenesis in solutions of glutathione S-transferase-huntingtin (GST-HD) fusion proteins has been studied by using dynamic light scattering, which provides a powerful tool for the quantitative assay of GST-HD fibrillsogenesis in vitro.
Journal ArticleDOI
Aggregation of truncated GST-HD exon 1 fusion proteins containing normal range and expanded glutamine repeats.
Birgit Hollenbach,Eberhard Scherzinger,Katja Schweiger,Rudi Lurz,Hans Lehrach,Erich E. Wanker +5 more
TL;DR: It is reported that a truncated GST HD exon 1 fusion protein with 51 glutamine residues, which lacks the proline-rich region C-terminal to the polyglutamine (polyQ) tract (GST-HD51 delta P) self-aggregates into high-molecular-mass protein aggregates without prior proteolytic cleavage.