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Björn Fischler
Researcher at Karolinska University Hospital
Publications - 147
Citations - 4362
Björn Fischler is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Cholestasis & Biliary atresia. The author has an hindex of 30, co-authored 133 publications receiving 3535 citations. Previous affiliations of Björn Fischler include Karolinska Institutet.
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Journal ArticleDOI
Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency.
A.S. Knisely,Sandra Strautnieks,Yvonne Meier,Bruno Stieger,J A Byrne,Bernard Portmann,Laura N. Bull,Ludmila Pawlikowska,Banu Bilezikçi,Figen Özçay,Aranka László,László Tiszlavicz,Lynette Moore,Jeremy Raftos,Henrik Arnell,Björn Fischler,Antal Nemeth,Nikos Papadogiannakis,Joanna Cielecka-Kuszyk,Irena Jankowska,Joanna Pawłowska,Hector Melin-Aldana,Karan M. Emerick,Peter F. Whitington,Giorgina Mieli-Vergani,Richard J. Thompson +25 more
TL;DR: PFIC associated with BSEP deficiency represents a previously unrecognized risk for HCC in young children and correlates well with demonstrable mutation in ABCB11.
Journal ArticleDOI
Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.
S S Strautnieks,J A Byrne,Ludmila Pawlikowska,Dita Cebecauerova,Anne Rayner,Laura Dutton,Yvonne Meier,Anthony Antoniou,Bruno Stieger,Henrik Arnell,Figen Özçay,Hussa F. Al-Hussaini,Atif F. Bassas,Henkjan J. Verkade,Björn Fischler,Antal Nemeth,Radana Kotalova,Benjamin L. Shneider,Joanna Cielecka-Kuszyk,Patricia McClean,Peter F. Whitington,Etienne Sokal,Milan Jirsa,Sami Wali,Irena Jankowska,Joanna Pawłowska,Giorgina Mieli-Vergani,A.S. Knisely,Laura N. Bull,Richard J. Thompson +29 more
TL;DR: With this study, >100 ABCB11 mutations are now identified and close surveillance of BSEP-deficient patients retaining their native liver, particularly those carrying 2 null mutations, is essential.
Journal ArticleDOI
Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
Rima Fawaz,Ulrich Baumann,Udeme D. Ekong,Björn Fischler,Nedim Hadzic,Cara L. Mack,Valérie A. McLin,Jean P. Molleston,Ezequiel Neimark,Vicky L. Ng,Saul J. Karpen +10 more
TL;DR: Any infant noted to be jaundiced after 2 weeks of age be evaluated for cholestasis with measurement of total and direct serum bilirubin, and that an elevated serum direct bilirUBin level warrants timely consideration for evaluation and referral to a pediatric gastroenterologist or hepatologist.
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Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.
Giorgina Mieli-Vergani,Diego Vergani,Ulrich Baumann,Piotr Czubkowski,Dominique Debray,Antal Dezsofi,Björn Fischler,Girish Gupte,Loreto Hierro,Giuseppe Indolfi,Jörg Jahnel,Françoise Smets,Henkjan J. Verkade,Nedim Hadžić +13 more
TL;DR: Paediatric autoimmune liver disease is characterised by inflammatory liver histology, circulating autoantibodies and increased levels of IgG, in the absence of a known etiology.
Journal ArticleDOI
Liver biopsy in children: position paper of the ESPGHAN Hepatology Committee.
Antal Dezsőfi,Ulrich Baumann,Anil Dhawan,Ozlem Durmaz,Björn Fischler,Nedim Hadzic,Loreto Hierro,F. Lacaille,Valérie A. McLin,Valerio Nobili,Piotr Socha,Pietro Vajro,A.S. Knisely +12 more
TL;DR: The aim of this position paper is to summarise the present practice of paediatric LB and make recommendations about its performance, with focus on the technique, indications, risk of complications, and contraindications in paediatrics.