B
Blanche Capel
Researcher at Duke University
Publications - 152
Citations - 18566
Blanche Capel is an academic researcher from Duke University. The author has contributed to research in topics: Gonad & Testis determining factor. The author has an hindex of 63, co-authored 146 publications receiving 16855 citations. Previous affiliations of Blanche Capel include National Institute for Medical Research & Fox Chase Cancer Center.
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Pdgfr-α mediates testis cord organization and fetal Leydig cell development in the XY gonad
TL;DR: Analysis of expression patterns and characterization of the gonad phenotype in Pdgfr-alpha(-/-) embryos identified PDGFR-alpha as a critical mediator of signaling in the early testis at multiple steps of testis development.
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Male-specific cell migration into the developing gonad.
TL;DR: It is suggested that migration of cells into the bipotential gonad may have a critical role in initiating the divergence of development towards the testis pathway.
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Follistatin Operates Downstream of Wnt4 in Mammalian Ovary Organogenesis
Humphrey H.-C. Yao,Martin M. Matzuk,Carolina J. Jorgez,Douglas B. Menke,David C. Page,Amanda Swain,Blanche Capel +6 more
TL;DR: This work shows that follistatin (Fst), which encodes a TGFβ superfamily binding protein, is a downstream component of Wnt4 signaling and proposes that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary.
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The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours
Kirsten K. Youngren,Douglas Coveney,Xiaoning Peng,Chitralekha Bhattacharya,Laura S. Schmidt,Michael L. Nickerson,Bruce T. Lamb,Jian Min Deng,Richard R. Behringer,Blanche Capel,Edward M. Rubin,Joseph H. Nadeau,Angabin Matin +12 more
TL;DR: The positional cloning of Ter is reported, revealing a point mutation that introduces a termination codon in the mouse orthologue (Dnd1) of the zebrafish dead end (dnd) gene that may adversely affect essential aspects of RNA biology during PGC development.
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Sry induces cell proliferation in the mouse gonad
TL;DR: An increase in cell proliferation in the male coelomic epithelium is the earliest identified effect of Sry expression, and it is found that the size increase corresponds with a dramatic increase in somaticcell proliferation in XY gonads, which is not detected in XX gonads.