Bo Wei

TL;DR: HECT domain and RLD 5 is identified as a specific binding protein of IRF3 by immunoprecipitation and characterizes HERC5 as a positive regulator of innate antiviral responses, which sustainsIRF3 activation via a novel posttranslational modification, ISGylation.

TL;DR: A software tool, miRPara, that predicts most probable mature miRNA coding regions from genome scale sequences in a species specific manner and achieves an accuracy of up to 80% against experimentally verified mature miRNAs, making it one of the most accurate methods available.

TL;DR: TRIM21 (tripartite motif-containing 21) is significantly induced and interacts with IRF3 upon RNA virus infection and it positively regulates the strength and duration of primary antiviral response, thus further strengthening the notion that the TRIM family is evolutionarily integrated with innate immunity.

TL;DR: This study characterizes IFIT3 as an important modulator in innate immunity, revealing a new function of the IFIT family proteins (IFN-induced protein with tetratricopeptide repeats).

TL;DR: An evolutionary analysis based on 98 full-length genome sequences of JEV indicates that the genotypes diverged in the order IV, III, II, and I and that the genetic diversity of genotype III has decreased rapidly while that of genotypes I has increased gradually, consistent with its emergence as the dominant genotype.