Bo Zhang

TL;DR: The inhibition of USP39 expression decreased the phosphorylation of extracellular signal-regulated kinase (ERK)1/2, indicating that ERK signaling pathways might be involved in the regulation of melanoma cell proliferation by USP40.

TL;DR: This study is the first to show that these 5 susceptibility loci (8p12, 4q34.1/ADAM29, 2q14.2, 3p24.2/TGFBR2, and 16q12.2-FTO) correlate with breast cancer (overall and specific subtypes) in Chinese women, which has improved the understanding of the genetic basis of specific breast cancer subtypes.

TL;DR: Large-scale genetic screening identifies novel missense variants and a noncoding variant as predisposing factors for breast cancer and highlights a polygenic basis of disease development.

TL;DR: This study is the first to detect the regulation of lysine succinylation in breast cancer progression and identifies a novel mechanism by which the pentose phosphate pathway and the endoplasmic reticulum protein processing pathway might be regulated via lysin succinylated in their core enzymes.