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Xiu-Jie Wang
Researcher at Chinese Academy of Sciences
Publications - 144
Citations - 17939
Xiu-Jie Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Gene & Induced pluripotent stem cell. The author has an hindex of 58, co-authored 137 publications receiving 14363 citations. Previous affiliations of Xiu-Jie Wang include Rockefeller University & Peking Union Medical College.
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Journal ArticleDOI
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Guanqun Zheng,John Arne Dahl,Yamei Niu,Peter Fedorcsak,Chun-Min Huang,Charles J. Li,Cathrine Broberg Vågbø,Yue Shi,Yue Shi,Wen-Ling Wang,Wen-Ling Wang,Shuhui Song,Zhike Lu,Ralph P. G. Bosmans,Qing Dai,Ya-Juan Hao,Ya-Juan Hao,Xin Yang,Xin Yang,Wenming Zhao,Wei-Min Tong,Xiu-Jie Wang,Florian Bogdan,Kari Furu,Ye Fu,Guifang Jia,Xu Zhao,Xu Zhao,Jun Liu,Hans E. Krokan,Arne Klungland,Yun-Gui Yang,Yun-Gui Yang,Chuan He +33 more
TL;DR: The discovery of ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo strongly suggests that the reversible m( 6)A modification has fundamental and broad functions in mammalian cells.
Journal ArticleDOI
Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
Wen Xiao,Samir Adhikari,Samir Adhikari,Ujwal Dahal,Ujwal Dahal,Yu-Sheng Chen,Yu-Sheng Chen,Ya-Juan Hao,Ya-Juan Hao,Bao-Fa Sun,Hui-Ying Sun,Hui-Ying Sun,Ang Li,Ang Li,Xiao-Li Ping,Weiyi Lai,Xing Wang,Xing Wang,Hai-Li Ma,Hai-Li Ma,Chun-Min Huang,Ying Yang,Niu Huang,Guibin Jiang,Hailin Wang,Qi Zhou,Xiu-Jie Wang,Yong-Liang Zhao,Yun-Gui Yang,Yun-Gui Yang +29 more
TL;DR: The findings provide the direct evidence that m(6)A reader YTHDC1 regulates mRNA splicing through recruiting and modulating pre-mRNA splicing factors for their access to the binding regions of targeted mRNAs.
Journal ArticleDOI
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
Xu Zhao,Ying Yang,Bao-Fa Sun,Yue Shi,Xin Yang,Wen Xiao,Ya-Juan Hao,Xiao-Li Ping,Yu-Sheng Chen,Wenjia Wang,Kang-Xuan Jin,Xing Wang,Chun-Min Huang,Yu Fu,Xiaomeng Ge,Shuhui Song,Hyun Seok Jeong,Hiroyuki Yanagisawa,Yamei Niu,Guifang Jia,Wei Wu,Wei-Min Tong,Akimitsu Okamoto,Chuan He,Jannie M. Rendtlew Danielsen,Xiu-Jie Wang,Yun-Gui Yang +26 more
TL;DR: Findings provide compelling evidence that FTO-dependent m6A demethylation functions as a novel regulatory mechanism of RNA processing and plays a critical role in the regulation of adipogenesis.
Journal ArticleDOI
GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis
Qi Zheng,Xiu-Jie Wang +1 more
TL;DR: An easy-to-use web-based toolkit that identifies statistically overrepresented GO terms within given gene sets and allows cross comparison of the GO enrichment status of multiple experiments to identify functional correlations among them.
Journal ArticleDOI
Draft genome of the wheat A-genome progenitor Triticum urartu
Hong-Qing Ling,Shancen Zhao,Dongcheng Liu,Junyi Wang,Hua Sun,Chi Zhang,Huajie Fan,Dong Li,Lingli Dong,Yong Tao,Chuan Gao,Huilan Wu,Yiwen Li,Yan Cui,Xiaosen Guo,Shusong Zheng,Biao Wang,Kang Yu,Qinsi Liang,Wenlong Yang,Xueyuan Lou,Jie Chen,Mingji Feng,Jianbo Jian,Xiaofei Zhang,Guangbin Luo,Ying Jiang,Junjie Liu,Zhaobao Wang,Yuhui Sha,Bairu Zhang,Hua-Jun Wu,Dingzhong Tang,Qian-Hua Shen,Pengya Xue,Shenhao Zou,Xiu-Jie Wang,Xin Liu,Famin Wang,Yanping Yang,Xueli An,Zhenying Dong,Kunpu Zhang,Xiangqi Zhang,Ming-Cheng Luo,Jan Dvorak,Yiping Tong,Jian Wang,Huanming Yang,Zhensheng Li,Daowen Wang,Aimin Zhang,Jun Wang,Jun Wang +53 more
TL;DR: The T. urartu genome assembly provides a diploid reference for analysis of polyploid wheat genomes and is a valuable resource for the genetic improvement of wheat.