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Bogusław Kapelak
Researcher at Jagiellonian University Medical College
Publications - 220
Citations - 5084
Bogusław Kapelak is an academic researcher from Jagiellonian University Medical College. The author has contributed to research in topics: Aortic valve replacement & Coronary artery disease. The author has an hindex of 23, co-authored 201 publications receiving 4502 citations. Previous affiliations of Bogusław Kapelak include University of Maryland, Baltimore & Jagiellonian University.
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Journal ArticleDOI
Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
Henry Krum,Markus P. Schlaich,Robert Whitbourn,Paul A. Sobotka,Jerzy Sadowski,Krzysztof Bartus,Bogusław Kapelak,Anthony Walton,Horst Sievert,S. Thambar,William T. Abraham,Murray D. Esler +11 more
TL;DR: In this article, a proof-of-principle trial of therapeutic renal sympathetic denervation in patients with resistant hypertension (i.e., systolic blood pressure ≥160 mm/hg on three or more antihypertensive medications, including a diuretic) was conducted to assess safety and blood-pressure reduction effectiveness.
Journal ArticleDOI
Percutaneous Left Atrial Appendage Suture Ligation Using the LARIAT Device in Patients With Atrial Fibrillation: Initial Clinical Experience
Krzysztof Bartus,Frederick T. Han,Jacek Bednarek,Jacek Myć,Bogusław Kapelak,Jerzy Sadowski,Jacek Lelakowski,Stanislaw Bartus,Steven J. Yakubov,Randall J. Lee +9 more
TL;DR: LAA closure with the LARIAT device can be performed effectively with acceptably low access complications and periprocedural adverse events in this observational study.
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Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease
Tomasz J. Guzik,Jerzy Sadowski,Bartłomiej Guzik,Andrew Jopek,Bogusław Kapelak,Piotr Przybyłowski,Karol Wierzbicki,Ryszard Korbut,David G. Harrison,Keith M. Channon +9 more
TL;DR: Increased expression and activity of NAD(P)H oxidase subunits and xanthine oxidase, in part mediated through angiotensin II and PKC-dependent pathways, are important mechanisms underlying increased oxidative stress in human coronary artery disease.
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Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease
Tomasz J. Guzik,Wei Chen,Maria Carolina Gongora,Bartłomiej Guzik,Heinrich E. Lob,Deepa Mangalat,Nyssa E. Hoch,Sergey Dikalov,Paweł Rudziński,Bogusław Kapelak,Jerzy Sadowski,David G. Harrison +11 more
TL;DR: Calcium-dependent NADPH-driven production of ROS in vascular membranes, reflecting NOX5 activity, was increased 7-fold in CAD and correlated significantly with NOx5 mRNA levels among subjects.
Journal ArticleDOI
Feasibility of closed-chest ligation of the left atrial appendage in humans
Krzysztof Bartus,Jacek Bednarek,Jacek Myć,Bogusław Kapelak,Jerzy Sadowski,Jacek Lelakowski,Steven J. Yakubov,Randall J. Lee +7 more
TL;DR: Catheter-based surgical suture ligation of the LAA is feasible in humans and may be appropriate for patients with atrial fibrillation who are ineligible for anticoagulation therapy.