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Boris P. Kopnin
Researcher at Russian Academy
Publications - 70
Citations - 2240
Boris P. Kopnin is an academic researcher from Russian Academy. The author has contributed to research in topics: Cell culture & Mutant. The author has an hindex of 26, co-authored 69 publications receiving 2139 citations. Previous affiliations of Boris P. Kopnin include Russian Academy of Sciences & Moscow State University.
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An attempt to prevent senescence: A mitochondrial approach
Vladimir P. Skulachev,Vladimir N. Anisimov,Yuri N. Antonenko,Lora E. Bakeeva,Boris V. Chernyak,V.P. Erichev,Oleg F. Filenko,Natalya I. Kalinina,Valery I. Kapelko,N. G. Kolosova,Boris P. Kopnin,Galina A. Korshunova,Mikhail R. Lichinitser,Lidia A. Obukhova,Elena G. Pasyukova,Oleg I. Pisarenko,Vitaly A. Roginsky,Enno K. Ruuge,Ivan I. Senin,Inna I. Severina,Maxim V. Skulachev,Irina Spivak,Vadim N. Tashlitsky,Vsevolod A. Tkachuk,Mikhail Yu. Vyssokikh,Lev S. Yaguzhinsky,Dmitry B. Zorov +26 more
TL;DR: In mammals, the effect of SkQs on aging was accompanied by inhibition of development of such age-related diseases and traits as cataract, retinopathy, glaucoma, balding, canities, osteoporosis, involution of the thymus, hypothermia, torpor, peroxidation of lipids and proteins, etc.
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Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability.
TL;DR: Changes in expression of sestrins can represent an important determinant of genetic instability in neoplastic cells showing simultaneous dysfunctions of Ras and p53, and several Ras effectors independently mediate ROS up-regulation.
Journal Article
Targets of oncogenes and tumor suppressors: key for understanding basic mechanisms of carcinogenesis.
TL;DR: Changes in expression of protooncogenes and tumor suppressor genes play a key role in oncogenesis and are obviously responsible for initial steps of neoplastic cell transformation and for determination of subsequent tumor progression resulting in the development of malignant tumors.
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells
L. S. Agapova,Boris V. Chernyak,Lidia V. Domnina,Vera Dugina,A. Yu. Efimenko,Fetisova Ek,O. Yu. Ivanova,Natalia Kalinina,N. V. Khromova,Boris P. Kopnin,Pavel Kopnin,M. V. Korotetskaya,Mikhail Lichinitser,A. L. Lukashev,O. Yu. Pletjushkina,E. N. Popova,Maxim V. Skulachev,Galina Shagieva,Stepanova Ev,E. Titova,Vsevolod A. Tkachuk,Jury M. Vasiliev,Jury M. Vasiliev,Vladimir P. Skulachev +23 more
TL;DR: Extremely high efficiency of SkQ1, related to its accumulation in the mitochondrial membrane, indicates that mitochondrial ROS production is critical for tumorigenesis at least in some animal models.
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Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.
Elena N. Pugacheva,Alexey V. Ivanov,Alexey V. Ivanov,Julia E. Kravchenko,Boris P. Kopnin,Arnold J. Levine,Arnold J. Levine,P. M. Chumakov,P. M. Chumakov,P. M. Chumakov +9 more
TL;DR: Conditional expression of His175 and Trp248 hot-spot p53 mutants in p53-negative mouse 10(1) fibroblasts and human SK-OV3 and H1299 tumor cells results in increase in dUTPase gene transcription, an important marker predicting the efficacy of cancer therapy with fluoropyrimidine drugs.