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Inna I. Severina
Researcher at Moscow State University
Publications - 33
Citations - 2101
Inna I. Severina is an academic researcher from Moscow State University. The author has contributed to research in topics: Membrane potential & Membrane. The author has an hindex of 20, co-authored 33 publications receiving 1945 citations. Previous affiliations of Inna I. Severina include Russian Academy of Sciences.
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Journal ArticleDOI
An attempt to prevent senescence: A mitochondrial approach
Vladimir P. Skulachev,Vladimir N. Anisimov,Yuri N. Antonenko,Lora E. Bakeeva,Boris V. Chernyak,V.P. Erichev,Oleg F. Filenko,Natalya I. Kalinina,Valery I. Kapelko,N. G. Kolosova,Boris P. Kopnin,Galina A. Korshunova,Mikhail R. Lichinitser,Lidia A. Obukhova,Elena G. Pasyukova,Oleg I. Pisarenko,Vitaly A. Roginsky,Enno K. Ruuge,Ivan I. Senin,Inna I. Severina,Maxim V. Skulachev,Irina Spivak,Vadim N. Tashlitsky,Vsevolod A. Tkachuk,Mikhail Yu. Vyssokikh,Lev S. Yaguzhinsky,Dmitry B. Zorov +26 more
TL;DR: In mammals, the effect of SkQs on aging was accompanied by inhibition of development of such age-related diseases and traits as cataract, retinopathy, glaucoma, balding, canities, osteoporosis, involution of the thymus, hypothermia, torpor, peroxidation of lipids and proteins, etc.
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies
Yuri N. Antonenko,A. V. Avetisyan,Lora E. Bakeeva,Boris V. Chernyak,Vyacheslav A. Chertkov,Lidia V. Domnina,O. Yu. Ivanova,D. S. Izyumov,Khailova Ls,S.S. Klishin,Galina A. Korshunova,Konstantin G. Lyamzaev,Maria S. Muntyan,O. K. Nepryakhina,A. A. Pashkovskaya,O. Yu. Pletjushkina,Antonina V. Pustovidko,Vitaly A. Roginsky,Tatyana I. Rokitskaya,Enno K. Ruuge,V. B. Saprunova,Inna I. Severina,Ruben A. Simonyan,I. V. Skulachev,Maxim V. Skulachev,Natalia V. Sumbatyan,I. V. Sviryaeva,Vadim N. Tashlitsky,J. M. Vassiliev,M. Yu. Vyssokikh,Lev S. Yaguzhinsky,Andrey A. Zamyatnin,Vladimir P. Skulachev +32 more
TL;DR: It is concluded that SkQs are rechargeable, mitochondria-targeted antioxidants of very high efficiency and specificity and might be used to effectively prevent ROS-induced oxidation of lipids and proteins in the inner mitochondrial membrane in vivo.
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Conversion of biomembrane-produced energy into electric form. II. Intact mitochondria
Lora E. Bakeeva,Lora E. Bakeeva,L.L. Grinius,L.L. Grinius,Audrius Jasaitis,Audrius Jasaitis,V.V. Kuliene,V.V. Kuliene,D.O. Levitsky,D.O. Levitsky,Liberman Ea,Liberman Ea,Inna I. Severina,Inna I. Severina,Vladimir P. Skulachev,Vladimir P. Skulachev +15 more
TL;DR: It is shown that anions of phenyl dicarbaundecaborane (PCB − ) are extruded from mitochondria on transition to the energized state, and the conclusion is confirmed that it is the electric field (negative inside the mitochondria) which is the motive force for the transport of penetrating ions across the mitochondrial membrane.
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Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore
Fedor F. Severin,Inna I. Severina,Yury N. Antonenko,Tatiana I. Rokitskaya,Dmitry A. Cherepanov,Elena N. Mokhova,Mikhail Yu. Vyssokikh,Antonina V. Pustovidko,Olga V. Markova,Lev S. Yaguzhinsky,Galina A. Korshunova,Nataliya V. Sumbatyan,Maxim V. Skulachev,Vladimir P. Skulachev +13 more
TL;DR: In isolated mitochondria, SkQ1 and C12TPP, but not cetyltrimethylammonium, potentiated fatty acid-induced (i) uncoupling of respiration and phosphorylation, and (ii) inhibition of H2O2 formation, stimulated respiration regardless of the extracellular pH value.
Journal ArticleDOI
Accumulation of lipophilic dications by mitochondria and cells
Meredith F. Ross,Tatiana Da Ros,Frances H. Blaikie,Tracy A. Prime,Carolyn M. Porteous,Inna I. Severina,Vladimir P. Skulachev,Henrik G. Kjaergaard,Robin A.J. Smith,Michael P. Murphy +9 more
TL;DR: The findings indicate that conjugating compounds to dications offers only a minor increase over monocations in delivery to mitochondria, and suggests that it may be possible to form dications within mitochondria that then remain within the cell.