L
Lev S. Yaguzhinsky
Researcher at Moscow State University
Publications - 91
Citations - 2127
Lev S. Yaguzhinsky is an academic researcher from Moscow State University. The author has contributed to research in topics: Mitochondrion & Membrane. The author has an hindex of 21, co-authored 86 publications receiving 1874 citations. Previous affiliations of Lev S. Yaguzhinsky include Moscow Institute of Physics and Technology & Laboratory of Molecular Biology.
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Journal ArticleDOI
An attempt to prevent senescence: A mitochondrial approach
Vladimir P. Skulachev,Vladimir N. Anisimov,Yuri N. Antonenko,Lora E. Bakeeva,Boris V. Chernyak,V.P. Erichev,Oleg F. Filenko,Natalya I. Kalinina,Valery I. Kapelko,N. G. Kolosova,Boris P. Kopnin,Galina A. Korshunova,Mikhail R. Lichinitser,Lidia A. Obukhova,Elena G. Pasyukova,Oleg I. Pisarenko,Vitaly A. Roginsky,Enno K. Ruuge,Ivan I. Senin,Inna I. Severina,Maxim V. Skulachev,Irina Spivak,Vadim N. Tashlitsky,Vsevolod A. Tkachuk,Mikhail Yu. Vyssokikh,Lev S. Yaguzhinsky,Dmitry B. Zorov +26 more
TL;DR: In mammals, the effect of SkQs on aging was accompanied by inhibition of development of such age-related diseases and traits as cataract, retinopathy, glaucoma, balding, canities, osteoporosis, involution of the thymus, hypothermia, torpor, peroxidation of lipids and proteins, etc.
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies
Yuri N. Antonenko,A. V. Avetisyan,Lora E. Bakeeva,Boris V. Chernyak,Vyacheslav A. Chertkov,Lidia V. Domnina,O. Yu. Ivanova,D. S. Izyumov,Khailova Ls,S.S. Klishin,Galina A. Korshunova,Konstantin G. Lyamzaev,Maria S. Muntyan,O. K. Nepryakhina,A. A. Pashkovskaya,O. Yu. Pletjushkina,Antonina V. Pustovidko,Vitaly A. Roginsky,Tatyana I. Rokitskaya,Enno K. Ruuge,V. B. Saprunova,Inna I. Severina,Ruben A. Simonyan,I. V. Skulachev,Maxim V. Skulachev,Natalia V. Sumbatyan,I. V. Sviryaeva,Vadim N. Tashlitsky,J. M. Vassiliev,M. Yu. Vyssokikh,Lev S. Yaguzhinsky,Andrey A. Zamyatnin,Vladimir P. Skulachev +32 more
TL;DR: It is concluded that SkQs are rechargeable, mitochondria-targeted antioxidants of very high efficiency and specificity and might be used to effectively prevent ROS-induced oxidation of lipids and proteins in the inner mitochondrial membrane in vivo.
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Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore
Fedor F. Severin,Inna I. Severina,Yury N. Antonenko,Tatiana I. Rokitskaya,Dmitry A. Cherepanov,Elena N. Mokhova,Mikhail Yu. Vyssokikh,Antonina V. Pustovidko,Olga V. Markova,Lev S. Yaguzhinsky,Galina A. Korshunova,Nataliya V. Sumbatyan,Maxim V. Skulachev,Vladimir P. Skulachev +13 more
TL;DR: In isolated mitochondria, SkQ1 and C12TPP, but not cetyltrimethylammonium, potentiated fatty acid-induced (i) uncoupling of respiration and phosphorylation, and (ii) inhibition of H2O2 formation, stimulated respiration regardless of the extracellular pH value.
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Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis.
Vladimir P. Skulachev,Lora E. Bakeeva,Boris V. Chernyak,Lidia V. Domnina,Alexander A. Minin,Olga Yu. Pletjushkina,V. B. Saprunova,Innokenty V Skulachev,Valeria G Tsyplenkova,Jury M. Vasiliev,Lev S. Yaguzhinsky,Dmitry B. Zorov +11 more
TL;DR: It is found that there is a lag phase between addition of an apoptogenic agent and the thread-grain transition and it is suggested that small mitochondria may serve as a transportable form of organelles (‘cargo boats’ transporting some apoptotic proteins to their nuclear targets).
Journal ArticleDOI
Oxygen-dependent auto-oscillations of water luminescence triggered by the 1264 nm radiation.
Sergey V. Gudkov,Vadim I. Bruskov,M. E. Astashev,A. V. Chernikov,Lev S. Yaguzhinsky,S D Zakharov +5 more
TL;DR: The results obtained suggest that auto-oscillations of water luminescence are triggered by photoinduced singlet oxygen (1)Δ(g), and this phenomenon is closely related to formation of hydrogen peroxide.