V
Vadim N. Tashlitsky
Researcher at Moscow State University
Publications - 76
Citations - 1746
Vadim N. Tashlitsky is an academic researcher from Moscow State University. The author has contributed to research in topics: Chemistry & Mitochondrion. The author has an hindex of 16, co-authored 67 publications receiving 1482 citations. Previous affiliations of Vadim N. Tashlitsky include I.M. Sechenov First Moscow State Medical University.
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Journal ArticleDOI
An attempt to prevent senescence: A mitochondrial approach
Vladimir P. Skulachev,Vladimir N. Anisimov,Yuri N. Antonenko,Lora E. Bakeeva,Boris V. Chernyak,V.P. Erichev,Oleg F. Filenko,Natalya I. Kalinina,Valery I. Kapelko,N. G. Kolosova,Boris P. Kopnin,Galina A. Korshunova,Mikhail R. Lichinitser,Lidia A. Obukhova,Elena G. Pasyukova,Oleg I. Pisarenko,Vitaly A. Roginsky,Enno K. Ruuge,Ivan I. Senin,Inna I. Severina,Maxim V. Skulachev,Irina Spivak,Vadim N. Tashlitsky,Vsevolod A. Tkachuk,Mikhail Yu. Vyssokikh,Lev S. Yaguzhinsky,Dmitry B. Zorov +26 more
TL;DR: In mammals, the effect of SkQs on aging was accompanied by inhibition of development of such age-related diseases and traits as cataract, retinopathy, glaucoma, balding, canities, osteoporosis, involution of the thymus, hypothermia, torpor, peroxidation of lipids and proteins, etc.
Journal ArticleDOI
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies
Yuri N. Antonenko,A. V. Avetisyan,Lora E. Bakeeva,Boris V. Chernyak,Vyacheslav A. Chertkov,Lidia V. Domnina,O. Yu. Ivanova,D. S. Izyumov,Khailova Ls,S.S. Klishin,Galina A. Korshunova,Konstantin G. Lyamzaev,Maria S. Muntyan,O. K. Nepryakhina,A. A. Pashkovskaya,O. Yu. Pletjushkina,Antonina V. Pustovidko,Vitaly A. Roginsky,Tatyana I. Rokitskaya,Enno K. Ruuge,V. B. Saprunova,Inna I. Severina,Ruben A. Simonyan,I. V. Skulachev,Maxim V. Skulachev,Natalia V. Sumbatyan,I. V. Sviryaeva,Vadim N. Tashlitsky,J. M. Vassiliev,M. Yu. Vyssokikh,Lev S. Yaguzhinsky,Andrey A. Zamyatnin,Vladimir P. Skulachev +32 more
TL;DR: It is concluded that SkQs are rechargeable, mitochondria-targeted antioxidants of very high efficiency and specificity and might be used to effectively prevent ROS-induced oxidation of lipids and proteins in the inner mitochondrial membrane in vivo.
Journal ArticleDOI
Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies.
Maxim V. Skulachev,Yuri N. Antonenko,Vladimir N. Anisimov,Boris V. Chernyak,Dmitry A. Cherepanov,Vladimir A. Chistyakov,M. V. Egorov,Nataliya G. Kolosova,Galina A. Korshunova,Konstantin G. Lyamzaev,Egor Y. Plotnikov,Vitaly A. Roginsky,A. Y. Savchenko,Inna I. Severina,Fedor F. Severin,T. P. Shkurat,Vadim N. Tashlitsky,K. M. Shidlovsky,Mikhail Yu. Vyssokikh,Andrey A. Zamyatnin,Dmitry B. Zorov,Vladimir P. Skulachev +21 more
TL;DR: It is suggested that the SkQs reduce mitochondrial ROS and, as a consequence, inhibit mitochondria-mediated apoptosis, an obligatory step of execution of programs responsible for both senescence and fast "biochemical suicide" of an organism after a severe metabolic crisis.
Journal ArticleDOI
Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs).
Vladimir P. Skulachev,Yury N. Antonenko,Dmitry A. Cherepanov,Boris V. Chernyak,D. S. Izyumov,Ludmila S. Khailova,S.S. Klishin,Galina A. Korshunova,Konstantin G. Lyamzaev,Olga Yu. Pletjushkina,Vitaly A. Roginsky,Tatiana I. Rokitskaya,Fedor F. Severin,Inna I. Severina,Ruben A. Simonyan,Maxim V. Skulachev,Natalia V. Sumbatyan,E. I. Sukhanova,Vadim N. Tashlitsky,T. A. Trendeleva,Mikhail Yu. Vyssokikh,Renata A. Zvyagilskaya +21 more
TL;DR: In mitochondria, the cycling gives rise to mild uncoupling, thereby decreasing membrane potential and ROS generation coupled to reverse electron transport in the respiratory chain and in yeast cells, dodecyltriphenylphosphonium (capital ES, Cyrillic12TPP), the cationic part of SkQ1, induces uncoupled that is mitochondria-targeted.
Journal ArticleDOI
Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome
Yury S. Polikanov,Ilya A. Osterman,Teresa Szal,Vadim N. Tashlitsky,Marina V. Serebryakova,Pavel A. Kusochek,David Bulkley,I. A. Malanicheva,T. A. Efimenko,Olga V. Efremenkova,Andrey L. Konevega,Karen J. Shaw,Alexey A. Bogdanov,Marina V. Rodnina,Olga A. Dontsova,Alexander S. Mankin,Thomas A. Steitz,Thomas A. Steitz,Petr V. Sergiev +18 more
TL;DR: It is demonstrated that the antibiotic amicoumacin A (AMI) is a potent inhibitor of protein synthesis and simultaneous interactions of AMI with 16S rRNA and mRNA and the in vivo experimental evidence suggest that it may inhibit the progression of the ribosome along mRNA.