Elena G. Pasyukova

TL;DR: In mammals, the effect of SkQs on aging was accompanied by inhibition of development of such age-related diseases and traits as cataract, retinopathy, glaucoma, balding, canities, osteoporosis, involution of the thymus, hypothermia, torpor, peroxidation of lipids and proteins, etc.

TL;DR: The nature of genetic variation for Drosophila longevity in a population of recombinant inbred lines was investigated, providing support for the pleiotropy theory of senescence and the hypothesis that variation for longevity might be maintained by opposing selection pressures in males and females and variable environments.

TL;DR: Late age-of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of senescence, and sex-specificQTL effects suggest a novel mechanism for maintaining genetic variation for lifespan.

TL;DR: Variation in the synthesis of bioamines as a factor contributing to natural variation in individual life span is implicate by mapping quantitative trait loci affecting variation in longevity between two Drosophila melanogaster strains.

TL;DR: Quantitative deficiency complementation is an efficient method for fine-scale QTL mapping in Drosophila and can be further improved by controlling the background genotype of the strains to be tested.