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Borivoj Vojnovic
Researcher at University of Oxford
Publications - 183
Citations - 7301
Borivoj Vojnovic is an academic researcher from University of Oxford. The author has contributed to research in topics: Microbeam & Cancer. The author has an hindex of 45, co-authored 183 publications receiving 6799 citations. Previous affiliations of Borivoj Vojnovic include Hillingdon Hospitals NHS Foundation Trust & VU University Amsterdam.
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Journal Article
Combretastatin A-4 Phosphate as a Tumor Vascular-Targeting Agent: Early Effects in Tumors and Normal Tissues
Gillian M. Tozer,Vivien E. Prise,John T. Wilson,R J Locke,Borivoj Vojnovic,Michael R.L. Stratford,Madeleine F. Dennis,David J. Chaplin +7 more
TL;DR: The potential for tumor vascular-targeting by using the tubulin destabilizing agent disodium combretastatin A-4 3-0-phosphate (CA-4-P) was assessed in a rat system as mentioned in this paper.
Journal Article
Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.
Gillian M. Tozer,Vivien E. Prise,John T. Wilson,Maja Cemazar,Siqing Shan,Mark W. Dewhirst,Paul R. Barber,Borivoj Vojnovic,David J. Chaplin +8 more
TL;DR: The tumor vascular effects of the tubulin destabilizing agent disodium combretastatinA-4 3-O-phosphate (CA-4-P) were investigated in the rat P22 tumor growing in a dorsal skin flap window chamber implanted into BD9 rats, and results suggest a mechanism of action of CA- 4-P in vivo.
Journal ArticleDOI
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.
Véronique Calleja,Damien Alcor,Michel Laguerre,Jongsun Park,Borivoj Vojnovic,Brian A. Hemmings,Julian Downward,Peter J. Parker,Banafshé Larijani +8 more
TL;DR: In vivo studies provide a new model for the mechanism of activation of PKB, and takes a crucial widely studied regulator and addresses the fundamental question of the dynamic in vivo behaviour of P KB with a detailed molecular mechanism.
Journal ArticleDOI
MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU
Elena Favaro,Elena Favaro,Anassuya Ramachandran,Robert McCormick,Harriet E. Gee,Christine Blancher,Meredith E. Crosby,Cecilia Devlin,Christopher Blick,Francesca M. Buffa,Ji-Liang Li,Borivoj Vojnovic,Ricardo Pires das Neves,Peter M. Glazer,Francisco J. Iborra,Mircea Ivan,Jiannis Ragoussis,Adrian L. Harris +17 more
TL;DR: Induction of these major hallmarks of cancer show that a single microRNA, miR-210, mediates a new mechanism of adaptation to hypoxia, by regulating mitochondrial function via iron-sulfur cluster metabolism and free radical generation.