J
Ji-Liang Li
Researcher at Southern Medical University
Publications - 88
Citations - 8710
Ji-Liang Li is an academic researcher from Southern Medical University. The author has contributed to research in topics: Angiogenesis & Notch signaling pathway. The author has an hindex of 42, co-authored 86 publications receiving 7819 citations. Previous affiliations of Ji-Liang Li include University of Plymouth & Tsinghua University.
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Journal ArticleDOI
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
Raju R. Raval,Kah Weng Lau,Maxine G. B. Tran,Heidi M. Sowter,Stefano J. Mandriota,Ji-Liang Li,Christopher W. Pugh,Patrick H. Maxwell,Adrian L. Harris,Peter J. Ratcliffe +9 more
TL;DR: HIF-α isoform-specific transcriptional selectivity was matched by differential effects on the growth of RCC as tumor xenografts, with HIF-1α retarding and Hif-2α enhancing tumor growth.
Journal ArticleDOI
The Bloom's syndrome gene product promotes branch migration of Holliday junctions
TL;DR: It is shown that BLM selectively binds Holliday junctions in vitro and acts on recombination intermediates containing a Holliday junction to promote ATP-dependent branch migration and present a model in which BLM disrupts potentially recombinogenic molecules that arise at sites of stalled replication forks.
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Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Karim Bensaad,Elena Favaro,Caroline A. Lewis,Barrie Peck,Simon Lord,Jennifer Collins,Katherine E. Pinnick,Simon Wigfield,Francesca M. Buffa,Ji-Liang Li,Qifeng Zhang,Michael J.O. Wakelam,Fredrik Karpe,Fredrik Karpe,Almut Schulze,Adrian L. Harris +15 more
TL;DR: In this paper, the authors identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake.
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Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
Cassin Kimmel Williams,Ji-Liang Li,Ji-Liang Li,Matilde Murga,Matilde Murga,Adrian L. Harris,Adrian L. Harris,Giovanna Tosato,Giovanna Tosato +8 more
TL;DR: The results identify the Notch ligand Dll4 as a selective inhibitor of V EGF-A biologic activities down-regulating 2 VEGF receptors expressed on endothelial cells and raise the possibility that Dll 4 may be exploited therapeutically to modulate angiogenesis.
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Up-regulation of Delta-like 4 Ligand in Human Tumor Vasculature and the Role of Basal Expression in Endothelial Cell Function
TL;DR: It is concluded that an optimal window of the DLL4 expression is essential for tumor angiogenesis and that selective modulation of the VEGF and basic fibroblast growth factor expression within human tumors may represent a potential novel antiangiogenic therapy.