B
Botond Sipos
Researcher at European Bioinformatics Institute
Publications - 24
Citations - 3356
Botond Sipos is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Gene & Nanopore sequencing. The author has an hindex of 15, co-authored 22 publications receiving 2698 citations. Previous affiliations of Botond Sipos include University of Oxford & Hungarian Academy of Sciences.
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Journal ArticleDOI
Towards practical, high-capacity, low-maintenance information storage in synthesized DNA
Nick Goldman,Paul Bertone,Siyuan Chen,Christophe Dessimoz,Emily M LeProust,Botond Sipos,Ewan Birney +6 more
TL;DR: Theoretical analysis indicates that the DNA-based storage scheme could be scaled far beyond current global information volumes and offers a realistic technology for large-scale, long-term and infrequently accessed digital archiving.
Journal ArticleDOI
Highly parallel direct RNA sequencing on an array of nanopores.
Daniel Ryan Garalde,Elizabeth A Snell,Daniel Jachimowicz,Botond Sipos,Joseph Hargreaves Lloyd,Mark Bruce,Nadia Pantic,Tigist Admassu,P. D. James,Anthony Warland,Michael I. Jordan,J. Ciccone,Sabrina Serra,Jemma Keenan,Samuel A.M. Martin,Luke A. McNeill,E. Jayne Wallace,Lakmal Jayasinghe,Christopher V.E. Wright,Javier Blasco,Stephen Young,Brocklebank D,Sissel Juul,James Clarke,Andrew John Heron,Daniel J. Turner +25 more
TL;DR: N nanopore direct RNA-seq is demonstrated, a highly parallel, real-time, single-molecule method that circumvents reverse transcription or amplification steps and enables the direct detection of nucleotide analogs in RNA.
Journal ArticleDOI
Systematic evaluation of spliced alignment programs for RNA-seq data
Pär G. Engström,Tamara Steijger,Botond Sipos,Gregory R. Grant,André Kahles,André Kahles,Gunnar Rätsch,Gunnar Rätsch,Nick Goldman,Tim Hubbard,Jennifer Harrow,Roderic Guigó,Paul Bertone +12 more
TL;DR: A comparison of 26 mapping protocols based on 11 programs and pipelines found major performance differences between methods on numerous benchmarks, including alignment yield, basewise accuracy, mismatch and gap placement, exon junction discovery and suitability of alignments for transcript reconstruction.
Journal ArticleDOI
Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome
Cornelis A. Albers,Ana Cvejic,Ana Cvejic,Rémi Favier,Evelien E. Bouwmans,Marie-Christine Alessi,Paul Bertone,Gregory E. Jordan,Ross Kettleborough,Graham Kiddle,Myrto Kostadima,Randy J. Read,Botond Sipos,Suthesh Sivapalaratnam,Peter A. Smethurst,Jonathan Stephens,Katrin Voss,Alan T. Nurden,Augusto Rendon,Augusto Rendon,Paquita Nurden,Willem H. Ouwehand,Willem H. Ouwehand +22 more
TL;DR: This work sequenced the exomes of four unrelated individuals and identified NBEAL2 as the causative gene; it has no previously known function but is a member of a gene family that is involved in granule development.
Journal ArticleDOI
Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster
Robert Markus,Barbara Laurinyecz,Éva Kurucz,Viktor Honti,Izabella Bajusz,Botond Sipos,Kálmán Somogyi,Jesper Kronhamn,Dan Hultmark,István Andó +9 more
TL;DR: The sessile hemocytes are defined as a novel hematopoietic compartment, and the main source of lamellocytes in Drosophila, which is analogous to the formation of granuloma in vertebrates.