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Brad R. Henke
Researcher at Research Triangle Park
Publications - 52
Citations - 4233
Brad R. Henke is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Agonist & Quorum sensing. The author has an hindex of 22, co-authored 52 publications receiving 3980 citations.
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Journal ArticleDOI
The PPARs: from orphan receptors to drug discovery.
Journal ArticleDOI
The PPARs: From Orphan Receptors to Drug Discovery
Journal ArticleDOI
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Kathleen K. Brown,Brad R. Henke,Steven G. Blanchard,Cobb Jeffrey Edmond,Robert A. Mook,Istvan Kaldor,Steve A. Kliewer,Jürgen M. Lehmann,James M. Lenhard,W W Harrington,P J Novak,W Faison,Jane G Binz,Mir Hashim,W O Oliver,H. R. Brown,Derek J. Parks,Kelli D. Plunket,W.Q. Tong,J A Menius,K Adkison,S A Noble,Timothy M. Willson +22 more
TL;DR: The increased potency of GW1929 compared with troglitazone both in vitro and in vivo may translate into improved clinical efficacy when used as monotherapy in type 2 diabetic patients, and a significant improvement in daily meal tolerance may impact cardiovascular risk factor management in these patients.
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Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing Receptors
Jon E. Paczkowski,Sampriti Mukherjee,Amelia R. McCready,Jian Ping Cong,Christopher Joseph Aquino,Hahn Kim,Brad R. Henke,Chari D. Smith,Bonnie L. Bassler +8 more
TL;DR: This work demonstrates that flavonoids specifically inhibit quorum sensing via antagonism of the autoinducer-binding receptors, LasR and RhlR, and confirms their potential as anti-infectives that do not function by traditional bacteriocidal or bacteriostatic mechanisms.
Journal ArticleDOI
3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats.
Timothy M. Willson,Brad R. Henke,Tanya M. Momtahen,Paul S. Charifson,Kenneth William Batchelor,Dennis B. Lubahn,Linda B. Moore,Beverly B. Oliver,Howard Ray Sauls,James A. Triantafillou,Steven G. Wolfe,Philip G. Baer +11 more