J
Jian Ping Cong
Researcher at Princeton University
Publications - 4
Citations - 511
Jian Ping Cong is an academic researcher from Princeton University. The author has contributed to research in topics: Quorum sensing & Autoinducer. The author has an hindex of 4, co-authored 4 publications receiving 384 citations. Previous affiliations of Jian Ping Cong include Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation
TL;DR: This work describes the first genome-wide annotation of transcriptional start sites in Vibrio cholerae and the discovery and characterization of a regulatory RNA, named VqmR, which controls collective behaviors in this major human pathogen.
Journal ArticleDOI
Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing Receptors
Jon E. Paczkowski,Sampriti Mukherjee,Amelia R. McCready,Jian Ping Cong,Christopher Joseph Aquino,Hahn Kim,Brad R. Henke,Chari D. Smith,Bonnie L. Bassler +8 more
TL;DR: This work demonstrates that flavonoids specifically inhibit quorum sensing via antagonism of the autoinducer-binding receptors, LasR and RhlR, and confirms their potential as anti-infectives that do not function by traditional bacteriocidal or bacteriostatic mechanisms.
Journal ArticleDOI
A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation
Kai Papenfort,Justin E. Silpe,Kelsey R. Schramma,Jian Ping Cong,Mohammad R. Seyedsayamdost,Bonnie L. Bassler,Bonnie L. Bassler +6 more
TL;DR: This work identifies and characterize a new QS autoinducer-receptor pair and proposes that DPO allows V. cholerae to regulate collective behaviors to diversify its QS output during colonization of the human host.
Journal ArticleDOI
An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
Jon E. Paczkowski,Amelia R. McCready,Jian Ping Cong,Jian Ping Cong,Zhijie Li,Philip D. Jeffrey,Chari D. Smith,Brad R. Henke,Frederick M. Hughson,Bonnie L. Bassler,Bonnie L. Bassler +10 more
TL;DR: The ability of LasR to bind ligands in different conformations, and in so doing, alter their potency as agonists, could explain the difficulties that have been encountered in the development of competitive LasR inhibitors.