Hahn Kim

TL;DR: The first enantioselective organocatalytic α-vinylation of aldehydes has been accomplished in this paper, where the SOMO-activated species undergo direct coupling with readily available potassium organotrifluoroborate salts to yield enantioenriched αvinyl aldehyde.

TL;DR: It is shown genetically that dual SHMT1/2 knockout blocks HCT-116 colon cancer tumor xenograft formation and defective glycine import is a targetable metabolic deficiency of DLBCL.

TL;DR: This work demonstrates that flavonoids specifically inhibit quorum sensing via antagonism of the autoinducer-binding receptors, LasR and RhlR, and confirms their potential as anti-infectives that do not function by traditional bacteriocidal or bacteriostatic mechanisms.

TL;DR: A compound is characterized that kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism of action (MoA) with undetectably low resistance frequencies, and suggests that combining multiple MoAs onto a single chemical scaffold may be an underappreciated approach to targeting challenging bacterial pathogens.

TL;DR: The combination of the glycosylation and subsequent functionalization provides a novel entry to saccharides which are otherwise difficult to prepare and should make this method a useful tool in synthetic carbohydrate chemistry.