Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing Receptors
Jon E. Paczkowski,Sampriti Mukherjee,Amelia R. McCready,Jian Ping Cong,Christopher Joseph Aquino,Hahn Kim,Brad R. Henke,Chari D. Smith,Bonnie L. Bassler +8 more
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TLDR
This work demonstrates that flavonoids specifically inhibit quorum sensing via antagonism of the autoinducer-binding receptors, LasR and RhlR, and confirms their potential as anti-infectives that do not function by traditional bacteriocidal or bacteriostatic mechanisms.About:
This article is published in Journal of Biological Chemistry.The article was published on 2017-03-10 and is currently open access. It has received 163 citations till now. The article focuses on the topics: Quorum sensing & Autoinducer.read more
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Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
TL;DR: The mechanism of antibiotic resistance in P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections.
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Comprehensive review of antimicrobial activities of plant flavonoids
TL;DR: The development and application of flavonoid-based drugs could be a promising approach for antibiotic-resistant infections and improve understanding of the biological and molecular roles of plant flavonoids, focusing mostly on their antimicrobial activities.
Journal ArticleDOI
Quorum-Sensing Systems as Targets for Antivirulence Therapy
TL;DR: An overview of the current knowledge of quorum-sensing systems of Gram-negative model pathogens is presented as well as the link with virulence of these pathogens, and recent advances and challenges in the development ofQuorum-Sensing-interfering therapies are discussed.
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Microbiologically influenced corrosion and current mitigation strategies: A state of the art review
TL;DR: This review evaluates different treatment methods and various techniques used to assess biocide treatment outcome including microbiology, molecular biology, corrosion testing and electrochemical methods.
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Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases.
TL;DR: Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti- QS agents are potential alternatives for antibiotics.
References
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Enzymatic assembly of DNA molecules up to several hundred kilobases
Daniel G. Gibson,Lei Young,Ray-Yuan Chuang,J. Craig Venter,Clyde A. Hutchison,Hamilton O. Smith +5 more
TL;DR: An isothermal, single-reaction method for assembling multiple overlapping DNA molecules by the concerted action of a 5′ exonuclease, a DNA polymerase and a DNA ligase is described.
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Origins and Evolution of Antibiotic Resistance
Julian Davies,Dorothy Davies +1 more
TL;DR: A review of antibiotic resistance development over the past half-century can be found in this article, with the oft-restated conclusion that it is time to act and to restore the therapeutic applications of antibiotics.
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QUORUM SENSING: Cell-to-Cell Communication in Bacteria
TL;DR: This review focuses on the architectures of bacterial chemical communication networks; how chemical information is integrated, processed, and transduced to control gene expression; how intra- and interspecies cell-cell communication is accomplished; and the intriguing possibility of prokaryote-eukaryote cross-communication.
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Chemistry and Biological Activities of Flavonoids: An Overview
Shashank Kumar,Abhay K. Pandey +1 more
TL;DR: The structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production are highlighted.
Origins and evolution of antibiotic resistance
TL;DR: This review presents the salient aspects of antibiotic resistance development over the past half-century, with the oft-restated conclusion that it is time to act.
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