B
Bradley D. Weaver
Researcher at University of Utah
Publications - 6
Citations - 688
Bradley D. Weaver is an academic researcher from University of Utah. The author has contributed to research in topics: Gene & Transcriptional regulation. The author has an hindex of 4, co-authored 5 publications receiving 394 citations. Previous affiliations of Bradley D. Weaver include Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Peter G. Hendrickson,Jessie Dorais,Jessie Dorais,Edward J. Grow,Jennifer L. Whiddon,Jong-Won Lim,Candice L. Wike,Bradley D. Weaver,Christian Pflueger,Benjamin R. Emery,Aaron L. Wilcox,David A. Nix,C. Matthew Peterson,Stephen J. Tapscott,Douglas T. Carrell,Bradley R. Cairns +15 more
TL;DR: Mouse DUX and human DUX4 are proposed as major drivers of the cleavage or 2C state, which is strongly resembling that of mouse 2C embryos.
Journal ArticleDOI
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Peter G. Hendrickson,Jessie Dorais,Edward J. Grow,Jennifer L. Whiddon,Jong-Won Lim,Candice L. Wike,Bradley D. Weaver,Christian Pflueger,Benjamin R. Emery,Aaron L. Wilcox,David A. Nix,C. Matthew Peterson,Stephen J. Tapscott,Douglas T. Carrell,Bradley R. Cairns +14 more
TL;DR: It is demonstrated that mouse DUX and human DUX4 are major drivers of gene activation during the cleavage or 2C state, and may have substantial implications for early embryo development, human infertility and recurrent pregnancy loss, cancer biology, and FSHD research.
Journal ArticleDOI
p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.
Edward J. Grow,Bradley D. Weaver,Christina M. Smith,Jingtao Guo,Paula Stein,Sean C. Shadle,Peter G. Hendrickson,Nicholas E. Johnson,Russell J. Butterfield,Roberta Menafra,Susan L. Kloet,Silvère M. van der Maarel,Carmen J. Williams,Bradley R. Cairns +13 more
TL;DR: Recently, this paper showed that p53 activation convergently evolved to couple p53 to Dux/DUX4 activation in embryonic stem cells, embryos and cells derived from patients with Facioscapulohumeral Muscular Dystrophy (FSHD).
Journal ArticleDOI
Concurrent Radiosurgery and Systemic Therapies for Melanoma Brain Metastases: A Systematic Review
TL;DR: A systematic review of the MEDLINE and Scopus databases found that concurrent SRS plus immunotherapy or BRAFi/MEKi is well tolerated by most patients and generally improved local control, distant control, and overall survival, and no significant increases in toxicities were noted with concurrent therapy.