J
Jong-Won Lim
Researcher at Fred Hutchinson Cancer Research Center
Publications - 13
Citations - 1269
Jong-Won Lim is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Gene & Geminin. The author has an hindex of 11, co-authored 13 publications receiving 963 citations. Previous affiliations of Jong-Won Lim include Washington University in St. Louis.
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Journal ArticleDOI
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Peter G. Hendrickson,Jessie Dorais,Jessie Dorais,Edward J. Grow,Jennifer L. Whiddon,Jong-Won Lim,Candice L. Wike,Bradley D. Weaver,Christian Pflueger,Benjamin R. Emery,Aaron L. Wilcox,David A. Nix,C. Matthew Peterson,Stephen J. Tapscott,Douglas T. Carrell,Bradley R. Cairns +15 more
TL;DR: Mouse DUX and human DUX4 are proposed as major drivers of the cleavage or 2C state, which is strongly resembling that of mouse 2C embryos.
Journal ArticleDOI
Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers
TL;DR: Direct transcriptional targets of the bHLH proteins Neurogenin and NeuroD are identified and it is found that primary roles of these transcription factors are to induce regulators of transcription, signal transduction, and cytoskeletal rearrangement for neuronal differentiation and migration.
Journal ArticleDOI
Geminin regulates neuronal differentiation by antagonizing Brg1 activity
Seongjin Seo,Anabel Herr,Jong-Won Lim,Genova A. Richardson,Helena E. Richardson,Kristen L. Kroll +5 more
TL;DR: Geminin is an essential regulator of neurogenesis that can control the timing of neural progenitor differentiation and maintain the undifferentiated cell state and is identified as an interacting partner of SWI/SNF chromatin-remodeling protein Brg1.
Journal ArticleDOI
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Peter G. Hendrickson,Jessie Dorais,Edward J. Grow,Jennifer L. Whiddon,Jong-Won Lim,Candice L. Wike,Bradley D. Weaver,Christian Pflueger,Benjamin R. Emery,Aaron L. Wilcox,David A. Nix,C. Matthew Peterson,Stephen J. Tapscott,Douglas T. Carrell,Bradley R. Cairns +14 more
TL;DR: It is demonstrated that mouse DUX and human DUX4 are major drivers of gene activation during the cleavage or 2C state, and may have substantial implications for early embryo development, human infertility and recurrent pregnancy loss, cancer biology, and FSHD research.
Journal ArticleDOI
Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo
TL;DR: Geminin is defined as an essential regulator of the embryonic transition from pluripotency through early multi-lineage commitment, and it is demonstrated that functional cooperativity between Geminin and Polycomb contributes to this process.