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Christian Pflueger
Researcher at University of Western Australia
Publications - 15
Citations - 1379
Christian Pflueger is an academic researcher from University of Western Australia. The author has contributed to research in topics: DNA methylation & Chromatin. The author has an hindex of 7, co-authored 10 publications receiving 951 citations. Previous affiliations of Christian Pflueger include Howard Hughes Medical Institute & University of Utah.
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Journal ArticleDOI
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Peter G. Hendrickson,Jessie Dorais,Jessie Dorais,Edward J. Grow,Jennifer L. Whiddon,Jong-Won Lim,Candice L. Wike,Bradley D. Weaver,Christian Pflueger,Benjamin R. Emery,Aaron L. Wilcox,David A. Nix,C. Matthew Peterson,Stephen J. Tapscott,Douglas T. Carrell,Bradley R. Cairns +15 more
TL;DR: Mouse DUX and human DUX4 are proposed as major drivers of the cleavage or 2C state, which is strongly resembling that of mouse 2C embryos.
Journal ArticleDOI
Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility
Saher Sue Hammoud,Jahnvi Purwar,Christian Pflueger,Bradley R. Cairns,Bradley R. Cairns,Douglas T. Carrell +5 more
TL;DR: Patients with male factor infertility had significantly increased methylation alteration at six of seven imprinted loci tested, with differences in significance observed between oligozoospermic and abnormal protamine patients, suggesting that risk of transmission of epigenetic alterations may be different with diagnoses.
Journal ArticleDOI
Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility
TL;DR: The data does not establish a causative relationship, but it does raise the possibility that the age-associated methylation of the candidate genes that the authors observe in sperm might contribute to the increased incidence of neuropsychiatric and other disorders in the offspring of older males.
Journal ArticleDOI
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons
Peter G. Hendrickson,Jessie Dorais,Edward J. Grow,Jennifer L. Whiddon,Jong-Won Lim,Candice L. Wike,Bradley D. Weaver,Christian Pflueger,Benjamin R. Emery,Aaron L. Wilcox,David A. Nix,C. Matthew Peterson,Stephen J. Tapscott,Douglas T. Carrell,Bradley R. Cairns +14 more
TL;DR: It is demonstrated that mouse DUX and human DUX4 are major drivers of gene activation during the cleavage or 2C state, and may have substantial implications for early embryo development, human infertility and recurrent pregnancy loss, cancer biology, and FSHD research.
Journal ArticleDOI
A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs.
Christian Pflueger,Dennis E.K. Tan,Tessa Swain,Tessa Swain,Trung V. Nguyen,Trung V. Nguyen,Jahnvi Pflueger,Jahnvi Pflueger,Christian M. Nefzger,Jose M. Polo,Jose M. Polo,Jose M. Polo,Ethan Ford,Ryan Lister,Ryan Lister +14 more
TL;DR: A modular dCas9-SunTag (dC9Sun-D3A) system that can recruit multiple DNMT3A catalytic domains to a target site for editing DNA methylation is developed, allowing accurate functional determination of the role ofDNA methylation at single loci.