B
Bradon R. McDonald
Researcher at University of Wisconsin-Madison
Publications - 37
Citations - 2368
Bradon R. McDonald is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Cancer & Genome. The author has an hindex of 17, co-authored 33 publications receiving 1839 citations. Previous affiliations of Bradon R. McDonald include Translational Genomics Research Institute & University of Arizona.
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Journal ArticleDOI
Convergent evolution of metabolic roles in bacterial co-symbionts of insects
TL;DR: It is reported that, despite at least 200 million years of divergence, the two Sulcia genomes have nearly identical gene content and gene order, and that despite being phylogenetically distant and drastically different in genome size and architecture, Hodgkinia and Baumannia have converged on gene sets conferring similar capabilities for essential amino acid biosynthesis.
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Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiont.
TL;DR: Using a combination of genome sequencing and high-throughput proteomics, it is shown that an α-Proteobacterial symbiont of cicadas has the unprecedented combination of an extremely small genome, a GC–biased base composition, and a coding reassignment of UGA Stop→Trp.
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Evolution and Ecology of Actinobacteria and Their Bioenergy Applications.
Gina R. Lewin,Camila Carlos,Camila Carlos,Marc G. Chevrette,Heidi A. Horn,Bradon R. McDonald,Bradon R. McDonald,Robert J. Stankey,Robert J. Stankey,Brian G. Fox,Cameron R. Currie,Cameron R. Currie +11 more
TL;DR: Together, the evolution of high cellulolytic ability and diverse chemistry, shaped by their ecological roles in nature, make Actinobacteria a promising group for the bioenergy industry.
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One Bacterial Cell, One Complete Genome
Tanja Woyke,Damon Tighe,Konstantinos Mavromatis,Alicia Clum,Alex Copeland,Wendy Schackwitz,Alla Lapidus,Dongying Wu,John P. McCutcheon,Bradon R. McDonald,Nancy A. Moran,James Bristow,Jan Fang Cheng +12 more
TL;DR: This study demonstrates the power of single cell genomics to generate a complete, high quality, non-composite reference genome within an environmental sample, which can be used for population genetic analyzes.
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The antimicrobial potential of Streptomyces from insect microbiomes
Marc G. Chevrette,Caitlin M Carlson,Humberto E. Ortega,Chris S. Thomas,Gene E. Ananiev,Kenneth J. Barns,Adam J. Book,Julian Cagnazzo,Camila Carlos,Will Flanigan,Kirk J. Grubbs,Heidi A. Horn,F. Michael Hoffmann,Jonathan L. Klassen,Jennifer J. Knack,Gina R. Lewin,Bradon R. McDonald,Laura K. Muller,Weilan G. P. Melo,Adrián A. Pinto-Tomás,Amber Schmitz,Evelyn Wendt-Pienkowski,Scott A. Wildman,Miao Zhao,Fan Zhang,Tim S. Bugni,David R. Andes,Mônica Tallarico Pupo,Cameron R. Currie +28 more
TL;DR: The antimicrobial potential of insect-associated Streptomyces is uncovered and a compound, cyphomycin, active against multidrug-resistant fungal pathogens is identified, indicating host microbiomes are feasible sources for drug discovery.