L
Laura K. Muller
Researcher at University of Wisconsin-Madison
Publications - 10
Citations - 1080
Laura K. Muller is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Geomyces & Pseudogymnoascus destructans. The author has an hindex of 7, co-authored 10 publications receiving 888 citations. Previous affiliations of Laura K. Muller include University of Minnesota & United States Geological Survey.
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Journal ArticleDOI
Frequent arousal from hibernation linked to severity of infection and mortality in bats with white-nose syndrome
DeeAnn M. Reeder,Craig L. Frank,Gregory G. Turner,Carol U. Meteyer,Allen Kurta,Eric R. Britzke,Megan E. Vodzak,Scott R. Darling,Craig W. Stihler,Alan C. Hicks,Roymon Jacob,Laura E. Grieneisen,Sarah A. Brownlee,Laura K. Muller,David S. Blehert +14 more
TL;DR: It is demonstrated that WNS-affected bats aroused to euthermic body temperatures more frequently than unaffected bats, likely contributing to subsequent mortality, and the number of arousal bouts since datalogger attachment significantly predicted date of death.
Journal ArticleDOI
The antimicrobial potential of Streptomyces from insect microbiomes
Marc G. Chevrette,Caitlin M Carlson,Humberto E. Ortega,Chris S. Thomas,Gene E. Ananiev,Kenneth J. Barns,Adam J. Book,Julian Cagnazzo,Camila Carlos,Will Flanigan,Kirk J. Grubbs,Heidi A. Horn,F. Michael Hoffmann,Jonathan L. Klassen,Jennifer J. Knack,Gina R. Lewin,Bradon R. McDonald,Laura K. Muller,Weilan G. P. Melo,Adrián A. Pinto-Tomás,Amber Schmitz,Evelyn Wendt-Pienkowski,Scott A. Wildman,Miao Zhao,Fan Zhang,Tim S. Bugni,David R. Andes,Mônica Tallarico Pupo,Cameron R. Currie +28 more
TL;DR: The antimicrobial potential of insect-associated Streptomyces is uncovered and a compound, cyphomycin, active against multidrug-resistant fungal pathogens is identified, indicating host microbiomes are feasible sources for drug discovery.
Journal ArticleDOI
Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
Yu Yun Chang,Gábor Juhász,Pankuri Goraksha-Hicks,Andrew M. Arsham,Daniel R. Mallin,Laura K. Muller,Thomas P. Neufeld +6 more
TL;DR: The well-known TOR substrate S6K (p70 ribosomal protein S6 kinase) has been shown to play a positive role in autophagy, which may serve to limit levels of autophagosome formation under conditions of continuously low TOR activity.
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Distribution and Environmental Persistence of the Causative Agent of White-Nose Syndrome, Geomyces Destructans, in Bat Hibernacula of the Eastern United States
Jeffrey M. Lorch,Laura K. Muller,Robin E. Russell,Michael O'Connor,Daniel L. Lindner,David S. Blehert +5 more
TL;DR: Analysis of sediment samples collected from 55 bat hibernacula both within and outside the known range of WNS indicates that the distribution of G. destructans is correlated with disease in hibernating bats and supports the hypothesis that the fungus is likely an exotic species in North America.
Journal ArticleDOI
Bat white-nose syndrome: a real-time TaqMan polymerase chain reaction test targeting the intergenic spacer region of Geomyces destructans
Laura K. Muller,Jeffrey M. Lorch,Daniel L. Lindner,Michael O'Connor,Andrea Gargas,David S. Blehert +5 more
TL;DR: A real-time TaqMan PCR test that detects DNA from G. destructans by targeting a portion of the multicopy intergenic spacer region of the rRNA gene complex, which is highly sensitive and provides a valuable tool for WNS diagnostics and research.