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Brenda Richards
Researcher at Genzyme
Publications - 15
Citations - 872
Brenda Richards is an academic researcher from Genzyme. The author has contributed to research in topics: Gene expression profiling & Serial analysis of gene expression. The author has an hindex of 10, co-authored 15 publications receiving 849 citations.
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Journal ArticleDOI
Multiplex PCR amplification from the CFTR gene using DNA prepared from buccal brushes/swabs
Brenda Richards,Joel Skoletsky,Anthony P. Shuber,Rosemary Balfour,Robert C Stern,Henry L. Dorkin,Richard B. Parad,David R. Witt,Katherine W. Klinger +8 more
TL;DR: The quality of DNA isolated from buccal cells collected in this manner has been sufficient to reproducibly support multiplex amplification of 5 exons within the CFTR gene, validating the use of DNA extracted from cheek cells collected on cytology brushes for use in genetic testing.
Journal ArticleDOI
Amplification of a highly polymorphic VNTR segment by the polymerase chain reaction.
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New insights into ADPKD molecular pathways using combination of SAGE and microarray technologies
Hervé Husson,Partha Manavalan,Viatcheslav R. Akmaev,Ryan J. Russo,Brian P. Cook,Brenda Richards,Dana Barberio,Dongyu Liu,Xiaohong Cao,Gregory M. Landes,Clarence J. Wang,Bruce L. Roberts,Katherine W. Klinger,Shelley A. Grubman,Douglas M. Jefferson,Oxana Ibraghimov-Beskrovnaya +15 more
TL;DR: This study has performed comprehensive high-throughput expression analysis of normal and ADPKD epithelia in a two-step fashion and may provide valuable insights into the pathophysiology of AD PKD and suggest potential therapeutic targets.
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Detection by PCR of a VNTR polymorphism at D4S43.
Journal ArticleDOI
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
Sharon D. Morgenbesser,Rajashree McLaren,Brenda Richards,Mindy Zhang,Viatcheslav R. Akmaev,Scott F. Winter,Nora D. Mineva,Paula J. Kaplan-Lefko,Barbara A. Foster,Brian P. Cook,Michael R. Dufault,Xiahong Cao,Clarence J. Wang,Beverly A. Teicher,Katherine W. Klinger,Norman M. Greenberg,Stephen L. Madden +16 more
TL;DR: A major focus of prostate cancer research has been to identify genes that are deregulated during tumor progression, potentially providing diagnostic markers and therapeutic targets.