G
Gregory M. Landes
Researcher at Genzyme
Publications - 36
Citations - 4641
Gregory M. Landes is an academic researcher from Genzyme. The author has contributed to research in topics: Gene & PKD1. The author has an hindex of 22, co-authored 36 publications receiving 4510 citations. Previous affiliations of Gregory M. Landes include University of Utah & Johns Hopkins University.
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Journal ArticleDOI
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
Qing Wang,Mark E. Curran,Igor Splawski,Timothy C. Burn,J. M. Millholland,T. J. VanRaay,Jiaxiang Shen,Katherine W. Timothy,Vincent Gm,Vincent Gm,T. De Jager,Peter J. Schwartz,J.A. Towbin,Arthur J. Moss,Donald L. Atkinson,Gregory M. Landes,Timothy D. Connors,M T Keating +17 more
TL;DR: In this article, positional cloning was used to establish KVLQT1 as the chromosome 11-linked LQT 1 gene responsible for the most common inherited cardiac arrhythmia.
Journal ArticleDOI
Analysis of human transcriptomes
Victor E. Velculescu,Stephen L. Madden,Lin Zhang,Alex E Lash,Jian Yu,Carlo Rago,Anita Lal,Clarence Wang,Gary A. Beaudry,Kristin M Ciriello,Brian P. Cook,Michael R. Dufault,Anne T. Ferguson,Yuhong Gao,Tong-Chuan He,Heiko Hermeking,Siewleng K Hiraldo,Paul M. Hwang,Paul M. Hwang,Paul M. Hwang,Marissa A Lopez,Hilary F Luderer,Brynna Mathews,Joseph M. Petroziello,Kornelia Polyak,Leigh Zawel,Wen Zhang,Xiaoming Zhang,Wei Zhou,Wei Zhou,Frank G Haluska,Jin Jen,Saraswati Sukumar,Gregory M. Landes,Gregory J. Riggins,Bert Vogelstein,Bert Vogelstein,Kenneth W. Kinzler +37 more
TL;DR: Molecular biologists ought to respect the original definition of synteny and its etymological derivation, especially as this term is still needed to refer to genes located on the same chromosome.
Journal Article
Rapid detection of chromosome aneuploidies in uncultured amniocytes by using fluorescence in situ hybridization (FISH)
Katherine W. Klinger,Gregory M. Landes,Douglas C. Shook,Harvey R,Lopez L,Locke P,Terry J. Lerner,Osathanondh R,Leverone B,Houseal T +9 more
TL;DR: The combination of chromosome-specific probe sets composed primarily of cosmid contigs and optimized hybridization/detection allowed accurate chromosome enumeration in uncultured human amniotic fluid cells, consistent with the results obtained by traditional cytogenetic analysis.
Journal Article
Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer.
Mariana Nacht,Anne T. Ferguson,Wen Zhang,Joseph M. Petroziello,Brian P. Cook,Yu Hong Gao,Sharon Maguire,Deborah Riley,George Coppola,Gregory M. Landes,Stephen L. Madden,Saraswati Sukumar +11 more
TL;DR: Combining SAGE and custom array technology allowed for the rapid identification and validation of the clinical relevance of many genes potentially involved in breast cancer progression by finding genes consistently expressed at different levels in primary breast cancer, metastatic breast cancers, and normal mammary epithelial cells.
Journal ArticleDOI
Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat The AMERICAN PKD1 Consortium (APKD1 Consortium)
Timothy C. Burn,Timothy D. Connors,William R. Dackowski,Linda R. Petry,Terence J. Van Raay,John M. Millholland,Marc Venet,Glenn Miller,Ramond M. Hakim,Gregory M. Landes,Katherine W. Kilnger,Feng Qian,Luiz F. Onuchic,Terry Watnick,Gregory G. Germino,Norman A. Doggett +15 more
TL;DR: A leucine-rich repeat (LRR) motif was identified within the resulting predicted protein sequence of the PKD1 gene, and may explain some of the disease-related renal alterations such as mislocalization of membrane protein constituents and changes in the extracellular matrix organization.