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Brian J. McCarthy
Researcher at University of California, San Francisco
Publications - 62
Citations - 5486
Brian J. McCarthy is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gene & Apolipoprotein B. The author has an hindex of 35, co-authored 62 publications receiving 5437 citations. Previous affiliations of Brian J. McCarthy include University of California, Irvine.
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Journal ArticleDOI
Complete protein sequence and identification of structural domains of human apolipoprotein B
Timothy J. Knott,Richard J. Pease,L. M. Powell,S. Wallis,Stanley C. Rall,Thomas L. Innerarity,B D Blackhart,W. H. Taylor,Yves L. Marcel,Ross W. Milne,David W. Johnson,M. Fuller,Aldons J. Lusis,Brian J. McCarthy,Robert W. Mahley,B. Levy-Wilson,James F. Scott +16 more
TL;DR: The complete 4,563-amino-acid sequence of apo B-100 precursor (relative molecular mass (Mr) 514,000 (514K)) determined from complementary DNA clones is reported, identifying a domain enriched in basic amino-acid residues as important for the cellular uptake of cholesterol by the LDL receptor pathway.
Journal ArticleDOI
Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.
Luis F. Soria,E H Ludwig,Howard R. G. Clarke,Gloria Lena Vega,Scott M. Grundy,Brian J. McCarthy +5 more
TL;DR: It appears that the mutation in the codon for amino acid 3500 (CGG----CAG), a CG mutational "hot spot," defines a minor apoB-100 allele associated with defective low density lipoproteins and hypercholesterolemia.
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Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Thomas L. Innerarity,Robert W. Mahley,Karl H. Weisgraber,Thomas P. Bersot,Ronald M. Krauss,Gloria Lena Vega,Scott M. Grundy,W Friedl,Jean Davignon,Brian J. McCarthy +9 more
TL;DR: Familial defective apolipoprotein B-100 appears to be a significant genetic cause of hypercholesterolemia in Western societies.
Journal ArticleDOI
DNA sequence analysis of the transposon Tn3: three genes and three sites involved in transposition of Tn3.
TL;DR: Genetic data suggest that Tn3 contains a third site (Gill et al., 1978), designated IRS (internal resolution site), whose absence results in the insertion of two complete copies of Tn2 as direct repeats into the recipient DNA, and that the IRS site is required for recombination and subsequent segregation of the direct repeats to leave a single copy of TN3.
Journal ArticleDOI
Nucleotide sequence of the bacterial transposon Tn1681 encoding a heat-stable (ST) toxin and its identification in enterotoxigenic Escherichia coli strains
Magdalene So,Brian J. McCarthy +1 more
TL;DR: It is determined that the ST toxin with activity assayable in suckling mice (ST I) is genetically distinct from the St toxin assayability in ligated ileal loops (ST II) and that ST I can be responsible for diarrheal disease in different animals.