Nina F. Øbro

TL;DR: Analysis of blood from a healthy human show that haematopoietic stem cells increase rapidly in numbers through early life, reaching a stable plateau in adulthood, and contribute to myeloid and B lymphocyte populations throughout life.

TL;DR: NanoSeq as discussed by the authors is a duplex sequencing protocol with error rates of less than five errors per billion base pairs in single DNA molecules from cell populations, enabling the study of somatic mutations in any tissue independently of clonality.

TL;DR: Data implicate the immune cell microenvironment as a significant player in ET disease evolution and illustrate the utility of cytokines as potential biomarkers for reaching beyond genomic classification for disease stratification and monitoring.

TL;DR: A novel form of autosomal recessive IFNAR2 deficiency due to a null and common allele in Arctic populations is reported, broadening its clinical phenotype from diseases caused by live-attenuated viral vaccines to include life-threatening influenza and SARS-CoV-2.

TL;DR: In this paper , the authors sequenced whole genomes from 717 normal naive and memory B and T cells and haematopoietic stem cells and found that all lymphocyte subsets carried more point mutations and structural variants than stem cells, with higher burdens in memory cells than in naive cells and with T cells accumulating mutations at a higher rate throughout life.