M
Mary Pettinger
Researcher at Fred Hutchinson Cancer Research Center
Publications - 123
Citations - 10442
Mary Pettinger is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Women's Health Initiative & Hazard ratio. The author has an hindex of 47, co-authored 109 publications receiving 9646 citations. Previous affiliations of Mary Pettinger include Vanderbilt University & National Institutes of Health.
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Journal ArticleDOI
Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial.
Jane A. Cauley,John A Robbins,Zhao Chen,Steven R. Cummings,Rebecca D. Jackson,Andrea Z. LaCroix,Meryl S. LeBoff,Cora E. Lewis,Joan McGowan,Joan M. Neuner,Mary Pettinger,Marcia L. Stefanick,Jean Wactawski-Wende,Nelson B. Watts +13 more
TL;DR: It is demonstrated that estrogen plus progestin increases BMD and reduces the risk of fracture in healthy postmenopausal women and there was no net benefit when considering the effects of hormone therapy on other important disease outcomes in a global model.
Journal ArticleDOI
Inflammatory Biomarkers, Hormone Replacement Therapy, and Incident Coronary Heart Disease: Prospective Analysis From the Women's Health Initiative Observational Study
Aruna D. Pradhan,JoAnn E. Manson,Jacques E. Rossouw,David S. Siscovick,Charles P. Mouton,Nader Rifai,Robert B. Wallace,Rebecca D. Jackson,Mary Pettinger,Paul M. Ridker +9 more
TL;DR: These prospective findings indicate that CRP and IL-6 independently predict vascular events among apparently healthy postmenopausal women and that HRT increases CRP.
Journal ArticleDOI
Estrogen therapy and coronary-artery calcification.
JoAnn E. Manson,Matthew A. Allison,Jacques E. Rossouw,J. Jeffrey Carr,Robert Langer,Judith Hsia,Lewis H. Kuller,Barbara B. Cochrane,Julie R. Hunt,Shari E. Ludlam,Mary Pettinger,Margery Gass,Karen L. Margolis,Lauren Nathan,Judith K. Ockene,Ross L. Prentice,John A Robbins,Marcia L. Stefanick +17 more
TL;DR: The calcified-plaque burden in the coronary arteries after trial completion was lower in women assigned to estrogen than in those assigned to placebo, however, estrogen has complex biologic effects and may influence the risk of cardiovascular events and other outcomes through multiple pathways.
Journal ArticleDOI
Effects of Estrogen Plus Progestin on Gynecologic Cancers and Associated Diagnostic Procedures: The Women's Health Initiative Randomized Trial
Garnet L. Anderson,Howard L. Judd,Andrew M. Kaunitz,David H. Barad,Shirley A.A. Beresford,Shirley A.A. Beresford,Mary Pettinger,James H. Liu,S. Gene McNeeley,Ana Maria Lopez +9 more
TL;DR: This randomized trial suggests that continuous combined estrogen plus progestin therapy may increase the risk of ovarian cancer while producing endometrial cancer rates similar to placebo, and provides additional support for caution in the use of continuous combined hormones.
Journal ArticleDOI
Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer
Rowan T. Chlebowski,Karen C. Johnson,Charles Kooperberg,Mary Pettinger,Jean Wactawski-Wende,T E Rohan,Jacques E. Rossouw,Dorothy S. Lane,Mary Jo O'Sullivan,Shagufta Yasmeen,Robert A. Hiatt,James M. Shikany,Mara Z. Vitolins,Janu Khandekar,F. Allan Hubbell +14 more
TL;DR: Calcium and vitamin D supplementation did not reduce invasive breast cancer incidence in postmenopausal women and a relationship between total vitamin D intake and 25-hydroxyvitamin D levels with breast cancer risk was not supported.