Brian M. Cartwright

TL;DR: The results reveal a mechanism for the crosstalk between HR repair and NHEJ through the co-regulation of p53–RPA interaction by DNA-PK, ATM and ATR.

TL;DR: It is reported that ATR has an antiapoptotic activity at mitochondria in response to UV damage, and this activity is independent of its hallmark checkpoint/kinase activity and partner ATRIP.

TL;DR: It is demonstrated that progerin‐induced apoptosis could be rescued by XPA, suggesting that XPA‐replication fork binding may prevent apoptosis in HGPS cells, and sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy‐related progeroid syndromes.

TL;DR: Results suggest that upon DNA damage transport adaptor importin-α4 imports XPA into the nucleus in an ATR-dependent manner, while XAB1 has no role in this process, revealing a potential new therapeutic target for the sensitization of cancer cells to chemotherapy.

TL;DR: Excess fasting phosphorylation of muscle IRS‐1 at Ser636 may be a major cause of the insulin resistance seen in obesity and might prevent improvement in insulin responsiveness when exercise training is not accompanied by weight loss.