Institution
East Tennessee State University
Education•Johnson City, Tennessee, United States•
About: East Tennessee State University is a education organization based out in Johnson City, Tennessee, United States. It is known for research contribution in the topics: Wafer & Silicon. The organization has 8417 authors who have published 12312 publications receiving 215712 citations. The organization is also known as: ETSU.
Topics: Wafer, Silicon, Population, Layer (electronics), Single crystal
Papers published on a yearly basis
Papers
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TL;DR: A large-scale screen is described to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways.
Abstract: The mammalian central nervous system (CNS) contains a remarkable array of neural cells, each with a complex pattern of connections that together generate perceptions and higher brain functions. Here we describe a large-scale screen to create an atlas of CNS gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosome (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways. We illustrate the use of this atlas to derive novel insights into gene function in neural cells, and into principal steps of CNS development. The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community.
1,989 citations
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Daniel J. Klionsky1, Amal Kamal Abdel-Aziz2, Sara Abdelfatah3, Mahmoud Abdellatif4 +2980 more•Institutions (777)
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
1,129 citations
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TL;DR: A family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the beta-glucan receptor dectin-1, explaining why dectIn-1 deficiency was not associated with invasive fungal infections and highlighting the specific role of dect in human mucosal antifungal defense.
Abstract: Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which four women who were affected by either recurrent vulvovaginal candidiasis or onychomycosis had the early-stop-codon mutation Tyr238X in the β-glucan receptor dectin-1. The mutated form of dectin-1 was poorly expressed, did not mediate β-glucan binding, and led to defective production of cytokines (interleukin-17, tumor necrosis factor, and interleukin-6) after stimulation with β-glucan or Candida albicans. In contrast, fungal phagocytosis and fungal killing were normal in the patients, explaining why dectin-1 deficiency was not associated with invasive fungal infections and highlighting the specific role of dectin-1 in human mucosal antifungal defense.
693 citations
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TL;DR: This paper describes a program which, although not intended to meet the test, is a tentative step in that direction, a synthesis of earlier work on emotions, purpose, conversation, knowledge/belief acquisition.
Abstract: There has never been a serious effort made to produce a program which would pass Turing's well known test for artificial intelligence. The present paper describes a program which, although not intended to meet the test, is a tentative step in that direction. It is a synthesis of earlier work on emotions, purpose, conversation, knowledge/belief acquisition. Provision for the incorporation of additional aspects of A/I has been made.
689 citations
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TL;DR: It appears that there may be no substitute for greater muscular strength when it comes to improving an individual’s performance across a wide range of both general and sport specific skills while simultaneously reducing their risk of injury when performing these skills.
Abstract: This review discusses previous literature that has examined the influence of muscular strength on various factors associated with athletic performance and the benefits of achieving greater muscular strength. Greater muscular strength is strongly associated with improved force-time characteristics that contribute to an athlete’s overall performance. Much research supports the notion that greater muscular strength can enhance the ability to perform general sport skills such as jumping, sprinting, and change of direction tasks. Further research indicates that stronger athletes produce superior performances during sport specific tasks. Greater muscular strength allows an individual to potentiate earlier and to a greater extent, but also decreases the risk of injury. Sport scientists and practitioners may monitor an individual’s strength characteristics using isometric, dynamic, and reactive strength tests and variables. Relative strength may be classified into strength deficit, strength association, or strength reserve phases. The phase an individual falls into may directly affect their level of performance or training emphasis. Based on the extant literature, it appears that there may be no substitute for greater muscular strength when it comes to improving an individual’s performance across a wide range of both general and sport specific skills while simultaneously reducing their risk of injury when performing these skills. Therefore, sport scientists and practitioners should implement long-term training strategies that promote the greatest muscular strength within the required context of each sport/event. Future research should examine how force-time characteristics, general and specific sport skills, potentiation ability, and injury rates change as individuals transition from certain standards or the suggested phases of strength to another.
653 citations
Authors
Showing all 8470 results
Name | H-index | Papers | Citations |
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Darien Wood | 160 | 2174 | 136596 |
Nicholas J. Talley | 158 | 1571 | 90197 |
Paul E. Keck | 117 | 469 | 44869 |
Guy S. Salvesen | 116 | 337 | 75598 |
Andrew V. Schally | 102 | 1107 | 50314 |
Robert M. Hoffman | 101 | 1111 | 43463 |
Gustavo Turecki | 99 | 639 | 42223 |
Tetsuo Nagano | 96 | 490 | 34267 |
Stephan Arndt | 95 | 361 | 28816 |
Martin Hendry | 93 | 375 | 63965 |
Junjie Chen | 92 | 319 | 33469 |
Clive S. Grant | 91 | 323 | 28791 |
James M. Downey | 91 | 381 | 29506 |
Abba J. Kastin | 87 | 598 | 32864 |
Virginia A. LiVolsi | 86 | 583 | 32645 |