Z
Zhengke Li
Researcher at East Tennessee State University James H. Quillen College of Medicine
Publications - 32
Citations - 641
Zhengke Li is an academic researcher from East Tennessee State University James H. Quillen College of Medicine. The author has contributed to research in topics: DNA damage & Nucleotide excision repair. The author has an hindex of 9, co-authored 32 publications receiving 462 citations. Previous affiliations of Zhengke Li include Children's Hospital Los Angeles & Beckman Research Institute.
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Journal ArticleDOI
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.
Moises A. Serrano,Zhengke Li,Mohan Dangeti,Phillip R. Musich,Steve M. Patrick,Marina Roginskaya,Brian M. Cartwright,Yue Zou +7 more
TL;DR: The results reveal a mechanism for the crosstalk between HR repair and NHEJ through the co-regulation of p53–RPA interaction by DNA-PK, ATM and ATR.
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Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A
Steven M. Shell,Zhengke Li,Nikolozi Shkriabai,Mamuka Kvaratskhelia,Chris A. Brosey,Moises A. Serrano,Walter J. Chazin,Phillip R. Musich,Yue Zou +8 more
TL;DR: The results suggest that the ATR-XPA interaction mediated by the helix-turn-helix motif of XPA plays an important role in DNA-damage responses to promote cell survival and genomic stability after UV irradiation.
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ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1
Benjamin Hilton,Zhengke Li,Phillip R. Musich,Hui Wang,Brian M. Cartwright,Moises A. Serrano,Xiao Zhen Zhou,Kun Ping Lu,Yue Zou +8 more
TL;DR: It is reported that ATR has an antiapoptotic activity at mitochondria in response to UV damage, and this activity is independent of its hallmark checkpoint/kinase activity and partner ATRIP.
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A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy
Wenpeng Liu,Wenpeng Liu,Wenpeng Liu,Mian Zhou,Zhengke Li,Hongzhi Li,Piotr Polaczek,Huifang Dai,Qiong Wu,Changwei Liu,Changwei Liu,Kenneth K. Karanja,Vencat Popuri,Shu-ou Shan,Katharina Schlacher,Li Zheng,Judith L. Campbell,Binghui Shen +17 more
TL;DR: It is shown that homozygous deletion of DNA2 sensitizes cells to ionizing radiation and camptothecin (CPT), and C5 is an even more potent inhibitor of restart of stalled DNA replication forks and over-resection of nascent DNA in cells defective in replication fork protection, including BRCA2 and BOD1L.
Journal ArticleDOI
hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability
Zhengke Li,Bochao Liu,Weiwei Jin,Xiwei Wu,Mian Zhou,Vincent Wenzhe Liu,Vincent Wenzhe Liu,Ajay Goel,Zhiyuan Shen,Li Zheng,Binghui Shen +10 more
TL;DR: It is shown that DNA2 binds preferentially to centromeric DNA, and the DNA2 inhibitor C5 mimics DNA2 knockout and synergistically kills cancer cells when combined with an ATR inhibitor, providing mechanistic insights into how DNA2 supports replication of centromic DNA.