M
Moises A. Serrano
Researcher at East Tennessee State University
Publications - 9
Citations - 367
Moises A. Serrano is an academic researcher from East Tennessee State University. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 6, co-authored 9 publications receiving 311 citations. Previous affiliations of Moises A. Serrano include East Tennessee State University James H. Quillen College of Medicine.
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Journal ArticleDOI
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.
Moises A. Serrano,Zhengke Li,Mohan Dangeti,Phillip R. Musich,Steve M. Patrick,Marina Roginskaya,Brian M. Cartwright,Yue Zou +7 more
TL;DR: The results reveal a mechanism for the crosstalk between HR repair and NHEJ through the co-regulation of p53–RPA interaction by DNA-PK, ATM and ATR.
Journal ArticleDOI
Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A
Steven M. Shell,Zhengke Li,Nikolozi Shkriabai,Mamuka Kvaratskhelia,Chris A. Brosey,Moises A. Serrano,Walter J. Chazin,Phillip R. Musich,Yue Zou +8 more
TL;DR: The results suggest that the ATR-XPA interaction mediated by the helix-turn-helix motif of XPA plays an important role in DNA-damage responses to promote cell survival and genomic stability after UV irradiation.
Journal ArticleDOI
ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1
Benjamin Hilton,Zhengke Li,Phillip R. Musich,Hui Wang,Brian M. Cartwright,Moises A. Serrano,Xiao Zhen Zhou,Kun Ping Lu,Yue Zou +8 more
TL;DR: It is reported that ATR has an antiapoptotic activity at mitochondria in response to UV damage, and this activity is independent of its hallmark checkpoint/kinase activity and partner ATRIP.
Journal ArticleDOI
FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1
Xi Wu,Zizheng Dong,Chao J. Wang,Lincoln James Barlow,Valerie E. Fako,Moises A. Serrano,Yue Zou,Jing-Yuan Liu,Jing-Yuan Liu,Jian Ting Zhang +9 more
TL;DR: It is concluded that FASN regulates cellular response against genotoxic insults by up-regulating PARP-1 and DNA repair via NF-κB and SP1 and will have a profound impact on designing future treatment strategies.
Journal ArticleDOI
XPA-Mediated Regulation of Global Nucleotide Excision Repair by ATR Is p53-Dependent and Occurs Primarily in S-Phase
TL;DR: It is demonstrated that nucleotide excision repair (NER) is regulated by the ATR/p53 checkpoint via modulation of XPA nuclear import and that this regulation occurs in a cell cycle-dependent manner.