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Brian W. Brannigan
Researcher at Harvard University
Publications - Â 27
Citations - Â 20131
Brian W. Brannigan is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Epidermal growth factor receptor. The author has an hindex of 22, co-authored 27 publications receiving 18682 citations.
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Journal ArticleDOI
RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
David T. Miyamoto,Yu Zheng,Ben S. Wittner,Richard T. Lee,Huili Zhu,Katherine T. Broderick,Rushil Desai,Douglas B. Fox,Brian W. Brannigan,Julie Trautwein,Kshitij S. Arora,Niyati Desai,Douglas M. Dahl,Lecia V. Sequist,Matthew R. Smith,Ravi Kapur,Chin-Lee Wu,Toshi Shioda,Sridhar Ramaswamy,David T. Ting,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber +23 more
TL;DR: Analysis of circulating tumor cells from prostate cancer patients reveals a mechanism that contributes to treatment failure, and a non-invasive method to spot resistance by sequencing RNA transcripts in single circulating tumor Cells (CTCs) is developed.
Journal ArticleDOI
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
Daphne W. Bell,Ira Gore,Ross A. Okimoto,Godin-Heymann Nadia G,Raffaella Sordella,Roseann Mulloy,Sreenath V. Sharma,Brian W. Brannigan,Gayatry Mohapatra,Jeff Settleman,Daniel A. Haber +10 more
TL;DR: A family with multiple cases of non-small cell lung cancer associated with germline transmission of a specific secondary somatic mutation, EGFR T790M, is described, implicate altered EGFR signaling in genetic susceptibility to lung cancer.
Journal ArticleDOI
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
David T. Ting,Doron Lipson,Suchismita Paul,Brian W. Brannigan,Sara Akhavanfard,Erik J. Coffman,Gianmarco Contino,Vikram Deshpande,A. John Iafrate,Stan Letovsky,Miguel Rivera,Nabeel Bardeesy,Shyamala Maheswaran,Daniel A. Haber +13 more
TL;DR: The overexpression of satellite transcripts in cancer may reflect global alterations in heterochromatin silencing and could potentially be useful as a biomarker for cancer detection.
Journal ArticleDOI
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
Min Yu,David T. Ting,Shannon L. Stott,Ben S. Wittner,Fatih Ozsolak,Suchismita Paul,Jordan C. Ciciliano,Malgorzata E. Smas,Daniel Winokur,Anna J. Gilman,Matthew J. Ulman,Kristina Xega,Gianmarco Contino,Brinda Alagesan,Brian W. Brannigan,Patrice M. Milos,David P. Ryan,Lecia V. Sequist,Nabeel Bardeesy,Sridhar Ramaswamy,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber +23 more
TL;DR: A microfluidic device is adapted for efficient capture of CTCs from an endogenous mouse pancreatic cancer model and single-molecule RNA sequencing is subjected, identifying Wnt2 as a candidate gene enriched in C TCs, to identify candidate therapeutic targets to prevent the distal spread of cancer.
Journal ArticleDOI
Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells
David T. Ting,Ben S. Wittner,Matteo Ligorio,Matteo Ligorio,Nicole Vincent Jordan,Ajay Shah,David T. Miyamoto,Nicola Aceto,Francesca Bersani,Brian W. Brannigan,Kristina Xega,Jordan C. Ciciliano,Huili Zhu,Olivia C. MacKenzie,Julie Trautwein,Kshitij S. Arora,Mohammad Shahid,Haley Ellis,Na Qu,Nabeel Bardeesy,Miguel Rivera,Vikram Deshpande,Cristina R. Ferrone,Ravi Kapur,Sridhar Ramaswamy,Toshi Shioda,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber +29 more
TL;DR: Mouse as well as human pancreatic CTCs exhibit a very high expression of stromal-derived extracellular matrix (ECM) proteins, including SPARC, whose knockdown in cancer cells suppresses cell migration and invasiveness, pointing to their contribution of microenvironmental signals for the spread of cancer to distant organs.