K
Kshitij S. Arora
Researcher at Harvard University
Publications - 29
Citations - 2121
Kshitij S. Arora is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 14, co-authored 28 publications receiving 1619 citations.
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Journal ArticleDOI
RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance
David T. Miyamoto,Yu Zheng,Ben S. Wittner,Richard T. Lee,Huili Zhu,Katherine T. Broderick,Rushil Desai,Douglas B. Fox,Brian W. Brannigan,Julie Trautwein,Kshitij S. Arora,Niyati Desai,Douglas M. Dahl,Lecia V. Sequist,Matthew R. Smith,Ravi Kapur,Chin-Lee Wu,Toshi Shioda,Sridhar Ramaswamy,David T. Ting,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber +23 more
TL;DR: Analysis of circulating tumor cells from prostate cancer patients reveals a mechanism that contributes to treatment failure, and a non-invasive method to spot resistance by sequencing RNA transcripts in single circulating tumor Cells (CTCs) is developed.
Journal ArticleDOI
Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells
David T. Ting,Ben S. Wittner,Matteo Ligorio,Matteo Ligorio,Nicole Vincent Jordan,Ajay Shah,David T. Miyamoto,Nicola Aceto,Francesca Bersani,Brian W. Brannigan,Kristina Xega,Jordan C. Ciciliano,Huili Zhu,Olivia C. MacKenzie,Julie Trautwein,Kshitij S. Arora,Mohammad Shahid,Haley Ellis,Na Qu,Nabeel Bardeesy,Miguel Rivera,Vikram Deshpande,Cristina R. Ferrone,Ravi Kapur,Sridhar Ramaswamy,Toshi Shioda,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber +29 more
TL;DR: Mouse as well as human pancreatic CTCs exhibit a very high expression of stromal-derived extracellular matrix (ECM) proteins, including SPARC, whose knockdown in cancer cells suppresses cell migration and invasiveness, pointing to their contribution of microenvironmental signals for the spread of cancer to distant organs.
Journal ArticleDOI
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Matteo Ligorio,Srinjoy Sil,Jose Malagon-Lopez,Linda T. Nieman,Sandra Misale,Mauro Di Pilato,Richard Y. Ebright,Murat Karabacak,Anupriya S. Kulkarni,A. W. K. Liu,Nicole Vincent Jordan,Joseph W. Franses,Julia Philipp,Johannes Kreuzer,Niyati Desai,Kshitij S. Arora,Mihir Rajurkar,Elad Horwitz,Azfar Neyaz,Eric Tai,Neelima K.C. Magnus,Kevin D. Vo,Chittampalli Yashaswini,Francesco Marangoni,Myriam Boukhali,Jackson P. Fatherree,Leah J. Damon,Kristina Xega,Rushil Desai,Melissa Choz,Francesca Bersani,Adam Langenbucher,Vishal Thapar,Robert Morris,Ulrich F. Wellner,Oliver Schilling,Michael S. Lawrence,Andrew S. Liss,Miguel Rivera,Vikram Deshpande,Cyril H. Benes,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Carlos Fernandez-del-Castillo,Cristina R. Ferrone,Wilhelm Haas,Martin J. Aryee,David T. Ting +48 more
TL;DR: The impact of the stroma is demonstrated in shaping tumor architecture by altering inherent patterns of tumor glands in human PDAC by quantifying EMT and PRO subpopulations in 319,626 individual cancer cells that can be classified within the context of distinct tumor gland "units".
Journal ArticleDOI
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
Sita Kugel,Carlos Sebastian,Julien Fitamant,Kenneth N. Ross,Supriya K. Saha,Esha Jain,Adrianne Gladden,Kshitij S. Arora,Yasutaka Kato,Miguel Rivera,Sridhar Ramaswamy,Ruslan I. Sadreyev,Alon Goren,Vikram Deshpande,Nabeel Bardeesy,Raul Mostoslavsky,Raul Mostoslavsky +16 more
TL;DR: An epigenetic program mediated by the NAD(+)-dependent histone deacetylase SIRT6 that is critical for suppression of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies is uncovered.
Journal ArticleDOI
Erratum to: The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology
Cristina R. Ferrone,David T. Ting,Mohammed Shahid,Ioannis Konstantinidis,Francesco Sabbatino,Lipika Goyal,Travis Rice-Stitt,Ayesha Mubeen,Kshitij S. Arora,Nabeel Bardeesey,John T. Miura,T. Clark Gamblin,Andrew X. Zhu,Darrell R. Borger,Keith D. Lillemoe,Miguel Rivera,Vikram Deshpande +16 more
TL;DR: Albumin RNA ISH is a sensitive and highly specific diagnostic tool for distinguishing ICC from metastatic adenocarcinoma to the liver or carcinoma of unknown origin, and could replace the extensive diagnostic workup, leading to timely confirmation of the ICC diagnosis.