B
Brian Y. Chow
Researcher at University of Pennsylvania
Publications - 57
Citations - 7285
Brian Y. Chow is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Optogenetics & Channelrhodopsin. The author has an hindex of 26, co-authored 52 publications receiving 6324 citations. Previous affiliations of Brian Y. Chow include McGovern Institute for Brain Research & Massachusetts Institute of Technology.
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Journal ArticleDOI
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Two channelrhodopsins, Chronos and Chrimson, are described, discovered through sequencing and physiological characterization of opsins from over 100 species of alga, that enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Independent optical excitation of distinct neural populations
Nathan C. Klapoetke,Yasunobu Murata,Sung Soo Kim,Stefan R. Pulver,Amanda Birdsey-Benson,Yong Ku Cho,Tania K. Morimoto,Amy S. Chuong,Eric J. Carpenter,Zhijian Tian,Jun Wang,Yinlong Xie,Zhixiang Yan,Yong Zhang,Brian Y. Chow,Barbara Surek,Michael Melkonian,Vivek Jayaraman,Martha Constantine-Paton,Gane Ka-Shu Wong,Edward S. Boyden +20 more
TL;DR: Chronos and Chrimson as mentioned in this paper have been shown to enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Journal ArticleDOI
High-performance genetically targetable optical neural silencing by light-driven proton pumps
Brian Y. Chow,Xue Han,Xue Han,Allison S. Dobry,Allison S. Dobry,Xiaofeng Qian,Xiaofeng Qian,Amy S. Chuong,Amy S. Chuong,Mingjie Li,Mingjie Li,Henninger Michael,Henninger Michael,Gabriel M. Belfort,Yingxi Lin,Patrick E. Monahan,Patrick E. Monahan,Edward S. Boyden,Edward S. Boyden +18 more
TL;DR: Light-driven proton pumps represent a high-performance and extremely versatile class of ‘optogenetic’ voltage and ion modulator, which will broadly enable new neuroscientific, biological, neurological and psychiatric investigations.
Journal ArticleDOI
A High-Light Sensitivity Optical Neural Silencer: Development and Application to Optogenetic Control of Non-Human Primate Cortex
Xue Han,Brian Y. Chow,Huihui Zhou,Nathan C. Klapoetke,Amy S. Chuong,Reza Rajimehr,Aimei Yang,Michael V. Baratta,Jonathan Andrew Winkle,Robert Desimone,Edward S. Boyden +10 more
TL;DR: The powerful net suppression of activity suggests that ArchT silencing technology might be of great use not only in the causal analysis of neural circuits, but may have therapeutic applications.
Journal ArticleDOI
Noninvasive optical inhibition with a red-shifted microbial rhodopsin
Amy S. Chuong,Mitra L Miri,Volker Busskamp,Gillian A. Matthews,Leah Acker,Andreas T. Sørensen,Andrew Young,Nathan C. Klapoetke,Henninger Michael,Suhasa B. Kodandaramaiah,Masaaki Ogawa,Shreshtha B. Ramanlal,Rachel C. Bandler,Brian D. Allen,Craig R. Forest,Brian Y. Chow,Xue Han,Yingxi Lin,Kay M. Tye,Botond Roska,Jessica A. Cardin,Edward S. Boyden +21 more
TL;DR: The red-shifted cruxhalorhodopsin, Jaws, derived from Haloarcula (Halobacterium) salinarum (strain Shark) and engineered to result in red light–induced photocurrents three times those of earlier silencers is presented, offering a powerful general-use chloride pump for basic and applied neuroscience.