Bridget M. Deasy

TL;DR: Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.

TL;DR: The transplantation of the long-time proliferating cells improved the efficiency of muscle regeneration and dystrophin delivery to dystrophic muscle and revealed the basis for the improvement of cell transplantation.

TL;DR: Findings indicate that TGF-beta1 is a major stimulator that plays a significant role in both the initiation of fibrotic cascades in skeletal muscle and the induction of myogenic cells to differentiate into myofibroblastic cells in injured muscle.

TL;DR: In this paper, the existence of cells with stem cell-like abilities derived from various tissues can now be extended to include the skeletal muscle compartment, and it is becoming increasingly apparent that such cells may one day be used in the treatment of non-myogenic disorders.

TL;DR: Myoendothelial cells regenerate myofibers in the injured skeletal muscle of severe combined immunodeficiency mice more effectively than CD56+ myogenic progenitors, are amenable to biotechnological handling, including purification by flow cytometry and long-term expansion in vitro, and may have potential for the treatment of human muscle disease.