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Britta M. Jacobsen
Researcher at Anschutz Medical Campus
Publications - 59
Citations - 3788
Britta M. Jacobsen is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Breast cancer & Estrogen receptor. The author has an hindex of 31, co-authored 59 publications receiving 3323 citations. Previous affiliations of Britta M. Jacobsen include Indiana University & Veterans Health Administration.
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Journal ArticleDOI
Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells.
Jennifer K. Richer,Britta M. Jacobsen,Nicole G. Manning,M. Greg Abel,Douglas M. Wolf,Kathryn B. Horwitz +5 more
TL;DR: This first, large scale study of PR gene regulation suggests that it is important to distinguish between the two isoforms in breast cancers and that isoform-specific genes can be used to screen for ligands that selectively modulate the activity of PR-A or PR-B.
Journal ArticleDOI
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide.
Dawn R. Cochrane,Sebastian Bernales,Britta M. Jacobsen,Diana M. Cittelly,Erin N. Howe,Nicholas C. D'Amato,Nicole S. Spoelstra,Susan M. Edgerton,Annie Jean,Javier Sanchez Guerrero,Francisco Gómez,Satyanarayana Medicherla,Iván E. Alfaro,Emma McCullagh,Paul Jedlicka,Kathleen C. Torkko,Ann D. Thor,Anthony D. Elias,Andrew Asher Protter,Jennifer K. Richer +19 more
TL;DR: This preclinical study supports the initiation of clinical studies evaluating enzalutamide for treatment of AR+ tumors regardless of ER status, since it blocks both androgen- and estrogen- mediated tumor growth.
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DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Christopher Korch,Monique A. Spillman,Twila A. Jackson,Britta M. Jacobsen,Susan K. Murphy,Bruce A. Lessey,V. Craig Jordan,Andrew P. Bradford +7 more
TL;DR: Significant misidentification, duplication, and loss of integrity of endometrial and ovarian cancer cell lines are demonstrated.
Journal ArticleDOI
Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.
TL;DR: Data indicate that hCGBP is a transcriptional activator that recognizes unmethylated CpG dinucleotides, suggesting a role in modulating the expression of genes located within C pG islands.
Journal ArticleDOI
Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo.
Valerie N. Barton,Nicholas C. D'Amato,Michael A. Gordon,Hanne T. Lind,Nicole S. Spoelstra,Beatrice Babbs,Richard Heinz,Anthony D. Elias,Paul Jedlicka,Britta M. Jacobsen,Jennifer K. Richer +10 more
TL;DR: It is indicated that non-LAR subtypes of TNBC are AR dependent and, moreover, that enzalutamide is a promising targeted therapy for multiple molecular sub types of AR+ TNBC.