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Brooke D. Esquivel
Researcher at University of Missouri–Kansas City
Publications - 13
Citations - 328
Brooke D. Esquivel is an academic researcher from University of Missouri–Kansas City. The author has contributed to research in topics: Azole & Efflux. The author has an hindex of 7, co-authored 10 publications receiving 197 citations.
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Journal ArticleDOI
Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae.
TL;DR: The data indicate that precise regulation of ERG genes is essential for cellular homeostasis and identify several ERg genes that could be exploited in future antifungal development efforts.
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Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris.
Jeffrey M. Rybak,José F. Muñoz,Katherine S. Barker,Josie E. Parker,Brooke D. Esquivel,Elizabeth L. Berkow,Shawn R. Lockhart,Lalitha Gade,Glen E. Palmer,Theodore C. White,Steve L. Kelly,Christina A. Cuomo,P. David Rogers +12 more
TL;DR: This work shows that mutations in the transcription factor TAC1B significantly contribute to clinical fluconazole resistance, and identifies this novel genetic determinant of resistance from C. auris from a global collection and appear specific to a subset of lineages or clades.
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Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling.
Nitesh Kumar Khandelwal,Nitesh Kumar Khandelwal,Neeraj Chauhan,Parijat Sarkar,Brooke D. Esquivel,Paola Coccetti,Ashutosh Singh,Ashutosh Singh,Alix T. Coste,Meghna Gupta,Meghna Gupta,Dominique Sanglard,Theodore C. White,Murielle Chauvel,Christophe d'Enfert,Amitabha Chattopadhyay,Naseem A. Gaur,Alok K. Mondal,Rajendra Prasad,Rajendra Prasad +19 more
TL;DR: This study uncovers a mechanism of azole resistance in C. albicans, involving increased membrane rigidity and TOR signaling, and grows NKKY101 cells on rapamycin and observed TOR1 hyperactivation, which leads to Hsp90-dependent calcineurin stabilization and thereby increased azoles resistance.
Journal ArticleDOI
Azole Drug Import into the Pathogenic Fungus Aspergillus fumigatus
TL;DR: In this article, the authors developed an assay to measure azole accumulation in Aspergillus fumigatus using radioactively labeled azole drugs, based on previous work done with C. albicans.
Journal ArticleDOI
Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae.
Brooke D. Esquivel,Jeffrey M. Rybak,Katherine S. Barker,Jarrod R. Fortwendel,P. David Rogers,Theodore C. White +5 more
TL;DR: Six A. fumigatus potential plasma membrane ABC transporter genes were analyzed and found that all six genes produced functional transporter proteins, demonstrating the high degree of phenotypic variation, plasticity, and divergence of which this species is capable.