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Bruce A. Pappas
Researcher at Carleton University
Publications - 78
Citations - 2778
Bruce A. Pappas is an academic researcher from Carleton University. The author has contributed to research in topics: Hydroxydopamine & Morris water navigation task. The author has an hindex of 30, co-authored 78 publications receiving 2700 citations. Previous affiliations of Bruce A. Pappas include University of Ottawa & University of California, San Diego.
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Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction
TL;DR: It is suggested that 2-VO causes neuronal dysfunction which can be exacerbated by stress and thereby manifested on aversively motivated tasks such as the water maze and reduced neuronal energy metabolism is associated with the progressive neurodegeneration that underlies disorders such as Alzheimer's.
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Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats.
J C de la Torre,T. Fortin,G.A.S. Park,K. Butler,Piotr Kozlowski,Bruce A. Pappas,H. De Socarraz,John K. Saunders,M. T. Richard +8 more
TL;DR: Cognitive, metabolic and morphologic damage was significantly more severe and longer lasting in aged than young rat brain after chronic CVI, and deficits observed in this rat model appear to mimic the early pathology reported in Alzheimer's disease.
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Potentiation of amygdala kindling in adult or infant rats by injections of 6-hydroxydopamine
TL;DR: These data confirm previous reports that the central catecholamines are capable of inhibiting a variety of forms of seizure and are replicated in two experiments using adult- and infant-injected rats.
Journal ArticleDOI
Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment.
Steffany A. L. Bennett,Martin Tenniswood,Jia-Hua Chen,Christopher M. Davidson,Marilyn T. Keyes,Teresa Fortin,Bruce A. Pappas +6 more
TL;DR: Data provide the first indication that apoptotic loss of pyramidal neurons may play a role in memory impairment associated with clinical conditions of chronic cerebrovascular insufficiency.
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Choline acetyltransferase activity and cognitive domain scores of Alzheimer's patients
TL;DR: Results are consistent with current animal research regarding the effect of selective cholinergic lesions on behavior.